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Receptor glukagonu sličnog peptida 2
Identifikatori
Simbol	GLP2R
Vanjski ID	OMIM: 603659 MGI: 2136733 HomoloGene: 3132 IUPHAR: GLP-2 GeneCards: GLP2R Gene
Ontologija gena
Molekularna funkcija	• aktivnost G protein spregnutog receptora; • aktivnost glukagonskog receptora;
Celularna komponenta	• integralno sa ćelijskom membranom; • integralno sa membranom;
Biološki proces	• metabolički proces energetske rezerve; • signalni put G-protein spregnutog receptor aktiviranog adenilat ciklazom; • aktivacija adenilat ciklazne aktivnosti;
Pregled RNK izražavanja
	podaci
Ortolozi

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Gen za receptor glukagonu sličnog peptida 2 (GLP-2) se nalazi na hromozomu 17.^[1]

Reference

↑ Brubaker PL, Drucker DJ (2002). „Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors”. Recept. Channels 8 (3–4): 179–88. DOI:10.1080/10606820213687. PMID 12529935. Arhivirano iz originala na datum 2006-10-20. Pristupljeno 2007-08-24.

Literatura

Burrin DG, Petersen Y, Stoll B, Sangild P (2001). „Glucagon-like peptide 2: a nutrient-responsive gut growth factor”. J. Nutr. 131 (3): 709–12. PMID 11238747.
Munroe DG, Gupta AK, Kooshesh F i dr.. (1999). „Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2”. Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1569–73. DOI:10.1073/pnas.96.4.1569. PMC 15520. PMID 9990065.
Yusta B, Huang L, Munroe D i dr.. (2000). „Enteroendocrine localization of GLP-2 receptor expression in humans and rodents”. Gastroenterology 119 (3): 744–55. DOI:10.1053/gast.2000.16489. PMID 10982769.
Thulesen J, Knudsen LB, Hartmann B i dr.. (2002). „The truncated metabolite GLP-2 (3-33) interacts with the GLP-2 receptor as a partial agonist”. Regul. Pept. 103 (1): 9–15. DOI:10.1016/S0167-0115(01)00316-0. PMID 11738243.
Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Koehler JA, Yusta B, Drucker DJ (2005). „The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways”. Mol. Endocrinol. 19 (2): 459–73. DOI:10.1210/me.2004-0196. PMID 15471943.
Ørskov C, Hartmann B, Poulsen SS i dr.. (2005). „GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors”. Regul. Pept. 124 (1–3): 105–12. DOI:10.1016/j.regpep.2004.07.009. PMID 15544847.
Mahon MJ, Shimada M (2005). „Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors”. FEBS Lett. 579 (3): 803–7. DOI:10.1016/j.febslet.2004.12.056. PMID 15670850.
Estall JL, Koehler JA, Yusta B, Drucker DJ (2005). „The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation”. J. Biol. Chem. 280 (23): 22124–34. DOI:10.1074/jbc.M500078200. PMID 15817468.
Guan X, Karpen HE, Stephens J i dr.. (2006). „GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow”. Gastroenterology 130 (1): 150–64. DOI:10.1053/j.gastro.2005.11.005. PMID 16401478.
Sams A, Hastrup S, Andersen M, Thim L (2006). „Naturally occurring glucagon-like peptide-2 (GLP-2) receptors in human intestinal cell lines”. Eur. J. Pharmacol. 532 (1–2): 18–23. DOI:10.1016/j.ejphar.2005.12.001. PMID 16448646.

Povezano

Vanjske veze

„Glucagon Receptor Family: GLP-2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2015-02-16.
MeSH glucagon-like+peptide+receptor

[pmid12529935-1] Brubaker PL, Drucker DJ (2002). „Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors”. Recept. Channels 8 (3–4): 179–88. DOI:10.1080/10606820213687. PMID 12529935. Arhivirano iz originala na datum 2006-10-20. Pristupljeno 2007-08-24.

[1]

Receptor glukagonu sličnog peptida 2

Reference

Literatura

Povezano

Vanjske veze