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Leukotrienski B4 receptor
Identifikatori
Simboli	LTB4R; BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1; P2RY7; P2Y7
Vanjski ID	OMIM: 601531 MGI: 1309472 HomoloGene: 22477 IUPHAR: BLT1 GeneCards: LTB4R Gene
Ontologija gena
Molekularna funkcija	• nukleotidno vezivanje; • aktivnost leukotrienskog B4 receptora; • aktivnost signalnog prenosnika; • receptorska aktivnost; • aktivnost leukotrienskog receptora;
Celularna komponenta	• ćelijska membrana; • integralno sa ćelijskom membranom;
Biološki proces	• komponenta ćelijskog kretanja; • kontrakcija mišića; • inflamatorni respons; • imunski respons; • signalni put G-protein spregnutog receptora; • aktivacija fosfolipaze C;
Ortolozi

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Leukotrienski B4 receptor 1 je protein koji je kod ljudi kodiran LTB4R genom.^[1]^[2]^[3]

Reference

↑ Owman C, Nilsson C, Lolait SJ (Feb 1997). „Cloning of cDNA encoding a putative chemoattractant receptor”. Genomics 37 (2): 187–94. DOI:10.1006/geno.1996.0541. PMID 8921391.
↑ Akbar GK, Dasari VR, Webb TE, Ayyanathan K, Pillarisetti K, Sandhu AK, Athwal RS, Daniel JL, Ashby B, Barnard EA, Kunapuli SP (Sep 1996). „Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells”. J Biol Chem 271 (31): 18363–7. DOI:10.1074/jbc.271.31.18363. PMID 8702478.
↑ „Entrez Gene: LTB4R leukotriene B4 receptor”.

Literatura

Raport CJ, Schweickart VL, Chantry D, et al. (1996). „New members of the chemokine receptor gene family.”. J. Leukoc. Biol. 59 (1): 18–23. PMID 8558062.
Tager AM, Luster AD (2004). „BLT1 and BLT2: the leukotriene B(4) receptors.”. Prostaglandins Leukot. Essent. Fatty Acids 69 (2-3): 123–34. DOI:10.1016/S0952-3278(03)00073-5. PMID 12895595.
Miyahara N, Miyahara S, Takeda K, Gelfand EW (2006). „Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation.”. Allergology international : official journal of the Japanese Society of Allergology 55 (2): 91–7. DOI:10.2332/allergolint.55.91. PMID 17075244.
Hillier LD, Lennon G, Becker M, et al. (1997). „Generation and analysis of 280,000 human expressed sequence tags.”. Genome Res. 6 (9): 807–28. DOI:10.1101/gr.6.9.807. PMID 8889549.
Yokomizo T, Izumi T, Chang K, et al. (1997). „A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis.”. Nature 387 (6633): 620–4. DOI:10.1038/42506. PMID 9177352.
Maier R, Glatz A, Mosbacher J, Bilbe G (1997). „Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.”. Biochem. Biophys. Res. Commun. 237 (2): 297–302. DOI:10.1006/bbrc.1997.7135. PMID 9268704.
Gaudreau R, Le Gouill C, Métaoui S, et al. (1998). „Signalling through the leukotriene B4 receptor involves both alphai and alpha16, but not alphaq or alpha11 G-protein subunits.”. Biochem. J. 335 (1): 15–8. PMC 1219746. PMID 9742207.
Kato K, Yokomizo T, Izumi T, Shimizu T (2000). „Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene.”. J. Exp. Med. 192 (3): 413–20. DOI:10.1084/jem.192.3.413. PMC 2193224. PMID 10934229.
Yokomizo T, Kato K, Terawaki K, et al. (2000). „A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders.”. J. Exp. Med. 192 (3): 421–32. DOI:10.1084/jem.192.3.421. PMC 2193217. PMID 10934230.
Stankova J, Turcotte S, Harris J, Rola-Pleszczynski M (2002). „Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival.”. J. Immunol. 168 (7): 3570–6. PMID 11907121.
Gaudreau R, Le Gouill C, Venne MH, et al. (2002). „Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization.”. J. Biol. Chem. 277 (35): 31567–76. DOI:10.1074/jbc.M202723200. PMID 12077128.
Hennig R, Ding XZ, Tong WG, et al. (2002). „5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue.”. Am. J. Pathol. 161 (2): 421–8. DOI:10.1016/S0002-9440(10)64198-3. PMC 1850753. PMID 12163367.
Ito N, Yokomizo T, Sasaki T, et al. (2003). „Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release.”. J. Biol. Chem. 277 (47): 44898–904. DOI:10.1074/jbc.M208051200. PMID 12244116.
Tong WG, Ding XZ, Hennig R, et al. (2003). „Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells.”. Clin. Cancer Res. 8 (10): 3232–42. PMID 12374694.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yokomizo T, Noiri E, Izumi T, Shimizu T (2003). „In vivo chemotaxis using CHO cells expressing human leukotriene B4 receptor.”. Adv. Exp. Med. Biol. 507: 357–61. PMID 12664610.

Povezano

Eikozanoidni receptor

Vanjske veze

„Leukotriene Receptors: BLT₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2013-03-14.
MeSH LTB4R+protein,+human
MeSH Receptors,+Leukotriene+B4

[pmid8921391-1] Owman C, Nilsson C, Lolait SJ (Feb 1997). „Cloning of cDNA encoding a putative chemoattractant receptor”. Genomics 37 (2): 187–94. DOI:10.1006/geno.1996.0541. PMID 8921391.

[pmid8702478-2] Akbar GK, Dasari VR, Webb TE, Ayyanathan K, Pillarisetti K, Sandhu AK, Athwal RS, Daniel JL, Ashby B, Barnard EA, Kunapuli SP (Sep 1996). „Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells”. J Biol Chem 271 (31): 18363–7. DOI:10.1074/jbc.271.31.18363. PMID 8702478.

[entrez-3] „Entrez Gene: LTB4R leukotriene B4 receptor”.

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