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5-hidroksitriptaminski (serotoninski) receptor 1A
5-hidroksitriptaminski (serotoninski) receptor 1A
Identifikatori
Simboli	HTR1A; 5-HT1A; 5HT1a; ADRB2RL1; ADRBRL1
Vanjski ID	OMIM: 109760 MGI: 96273 HomoloGene: 20148 IUPHAR: 5-HT1A GeneCards: HTR1A Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost; • serotoninska receptorska aktivnost;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• prenos signala; • signalni put G-protein spregnutog receptora; • ponašanje; • pozitivna regulacija ćelijske proliferacije;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	3350
Ensembl	ENSG00000178394
UniProt	P08908
RefSeq (mRNA)	NM_000524
RefSeq (protein)	NP_000515
Lokacija (UCSC)	Chr 5:; 63.29 - 63.29 Mb
PubMed pretraga	[1]

5-HT_1A receptor je tip 5-HT receptora za koji se vezuje endogeni neurotransmiter serotonin (5-hidroksitriptamin, 5-HT). On je G protein-spregnuti receptor (GPCR) koji je spregnut sa G_i/G_o i posreduje inhibitornu neurotransmisiju. Akronim HTR1A označava humani gen koji kodira ovaj receptor.^[1]^[2]

Distribucija

5-HT_1A receptor najšire rasprostranjen od svih 5-HT receptora. U centralnom nervnom sistemu, 5-HT_1A receptori se nalaze u cerebralnom kortesu, hipokampusu, septumu, amigdali, i rafovom jezgru u visokim koncentracijama, dok su u manjim količinama takođe prisutni u bazalnoj gangliji i talamusu.^[3]^[4]^[5]

Funkcija

Neuromodulacija

5-HT_1A receptorski agonisti snižavaju krvni pritisak i brzinu srca centralnim mehanizmom, indukcijom periferne vazodilaticije, i stimulacijom vagus nerva.^[6] Ti efekti su rezultat aktivacije 5-HT_1A receptora u rostralnoj ventrolateralnoj meduli.^[6] Simpatolitički antihipertenzivni lek urapidil je antagonist α₁-adrenergičkog receptora i agonist α₂-adrenergičkog receptora, kao i agonist 5-HT_1A receptora. Poznato je da ova zadnja osobina doprinosi njegovim sveukupnom terapeutskom dejstvu.^[7]^[8] Vazodilatacija krvnih sudova kože centralnom 5-HT_1A aktivacijom povećava toplotnu disipaciju sa organizma u okolnu sredinu, posledica čega je sniženje telesne temperature.^[9]^[10]

Aktivacija centralnih 5-HT_1A receptora inicira oslobađanje ili inhibiciju norepinefrina u zavisnosti od vrste, verovatno iz locus coeruleus regiona, što zatim dovodi do redukcije ili povišenja neuronskog tona sfinkter mišića zenice modulacijom postsinaptičkih α₂-adrenergički receptora unutar Edinger-Vestfalnog jezgra, što dovodi do dilatacije zenica kod glodara, i kontrakcije zenica kod primata uključujući ljude.^[11]^[12]^[13]

Agonisti 5-HT_1A receptora kao što su buspiron^[14] i flesinoksan^[15] su delotvorni u olakšavanju anksioznosti^[16] i depresije.^[17] Buspiron i tandospiron su trenutno odobreni za te indikacije u mnogim zemljama. Drugi, poput gepirona,^[18] flesinoksana,^[19] flibanserina,^[20] i PRX-00023^[21] su takođe bili ispitivani, mada još uvek nisu potpuno razvijeni i odobreni. Neki od atipičnih antipsihotika kao što je aripiprazol^[22] su takođe parcijalni agonisti 5-HT_1A receptora i ponekad se koriste u niskim dozama kao zamena za standardne antidepresive kao što su selektivni inhibitori preuzimanja serotonina (SSRI).^[23]

Endokrinologija

Aktivacija 5-HT_1A receptora indukuje sekreciju raznih hormona među kojima su kortizol, kortikosteron, adrenokortikotropni hormon (ACTH), oksitocin, prolaktin, hormon rasta, i β-endorfin.^[24]^[25]^[26]^[27] Ovaj receptor ne utiče na sekreciju vazopresina ili renina, za razliku od 5-HT₂ receptora.^[24]^[28] Postoje indikacije da otpuštanje oksitocina doprinosi prosocijalnim, antiagresivnim i anksiolitičkim svojstvima primećenim nakon aktivacije receptora.^[28] Moguće je da sekrecija β-endorfina doprinosi antidepresivnim, anksiolitičkim, i analgetskim efektima.

Ligandi

Distribucija 5-HT_1A receptora u ljudskom mozgu može biti snimljena pozitronskom emisionom tomografijom koristeći radioligand [¹¹C]WAY-100,635.^[29] Na primer, u jednoj studiji je utvrđeno povećano 5-HT_1A vezivanje kod tipa 2 dijabetesa.^[30] Jedna druga PET studija je utvrdila negativnu korelaciju između stepena 5-HT_1A vezivanja u rafijevom jezgru, hipokampusu i neokorteksu, i samo-prijavljene tendencije doživljavanja duhovnih iskustava.^[31] Kad je obeležen sa tricijumom, WAY-100,635 može takođe da se koristi u autoradiografiji.^[32]

Agonisti

Antagonisti

Genetika

5-HT_1A receptor je kodiran HTR1A genom. Postoji više humanih polimorfizama vezanih za ovaj gen. Jedan pregled iz 2007. navodi 27 jednonukleotidnih polimorfizama (SNP).^[33] Najviše istraženi su C-1019G (rs6295), C-1018G,^[34] Ile28Val (rs1799921), Arg219Leu (rs1800044), i Gly22Ser (rs1799920).^[33] Neki od preostalih SNP-ova su Pro16Leu, Gly272Asp, i sinonimni polimorfizam G294A (rs6294). Varijante ovog gena su bile studirane u vezi sa psihijatrijskim poremećajima, ali definitivni rezultati nisu dobijeni.^[33]

Interakcije

Za 5-HT_1A receptor je pokazano da interaguje sa moždanim neurotrofnim faktorom (BDNF), koji učestvuje u regulaciji raspoloženja i anksioznosti.^[35]^[36] Pokazano je da ostvaruje interakcije sa sfingozin-1-fosfatnim receptorom 1 (S1PR₁).^[37]

Vidi još

Reference

^ Gilliam TC, Freimer NB, Kaufmann CA, Powchik PP, Bassett AS, Bengtsson U, Wasmuth JJ (1989). „Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia”. Genomics. 5 (4): 940—4. PMID 2591972. doi:10.1016/0888-7543(89)90138-9.
^ „Entrez Gene: HTR1A 5-hydroxytryptamine (serotonin) receptor 1A”.
^ Ito H, Halldin C, Farde L (1999). „Localization of 5-HT1A receptors in the living human brain using [carbonyl-11C]WAY-100635: PET with anatomic standardization technique.”. J Nucl Med. 40 (1): 102—9. PMID 9935065.
^ Glennon RA, Dukat M, Westkaemper RB (1. 1. 2000). „Serotonin Receptor Subtypes and Ligands”. American College of Neurophyscopharmacology. Приступљено 11. 4. 2008.
^ de Almeida J, Mengod G (2008). „Serotonin 1A receptors in human and monkey prefrontal cortex are mainly expressed in pyramidal neurons and in a GABAergic interneuron subpopulation: implications for schizophrenia and its treatment.”. J Neurochem. 107 (2): 488—496. PMID 18761712. doi:10.1111/j.1471-4159.2008.05649.x.
^ ^а ^б Dabiré H. (1991). „Central 5-hydroxytryptamine (5-HT) receptors in blood pressure regulation.”. Therapie. 46 (6): 421—9. PMID 1819150.
^ Ramage AG (1991). „The mechanism of the sympathoinhibitory action of urapidil: role of 5-HT1A receptors”. Br. J. Pharmacol. 102 (4): 998—1002. PMC 1917978 . PMID 1855130.
^ Kolassa N, Beller KD, Sanders KH (1989). „Involvement of brain 5-HT1A receptors in the hypotensive response to urapidil.”. Am J Cardiol. 64 (7): 7D—10D. PMID 2569265. doi:10.1016/0002-9149(89)90688-7.
^ Ootsuka Y, Blessing WW (2006). „Activation of 5-HT1A receptors in rostral medullary raphé inhibits cutaneous vasoconstriction elicited by cold exposure in rabbits.”. Brain Res. 1073-1074: 252—61. PMID 16455061. doi:10.1016/j.brainres.2005.12.031.
^ Rusyniak DE, Zaretskaia MV, Zaretsky DV, DiMicco JA (2007). „3,4-Methylenedioxymethamphetamine- and 8-hydroxy-2-di-n-propylamino-tetralin-induced hypothermia: role and location of 5-hydroxytryptamine 1A receptors.”. J Pharmacol Exp Ther. 323 (2): 477—487. PMID 17702902. doi:10.1124/jpet.107.126169.
^ Yu Y, Ramage AG, Koss MC (2004). „Pharmacological studies of 8-OH-DPAT-induced pupillary dilation in anesthetized rats.”. Eur J Pharmacol. 489 (3): 207—213. PMID 15087245. doi:10.1016/j.ejphar.2004.03.007.
^ Prow MR, Martin KF, Heal DJ (1996). „8-OH-DPAT-induced mydriasis in mice: a pharmacological characterisation”. Eur J Pharmacol. 317 (1): 21—8. PMID 8982715. doi:10.1016/S0014-2999(96)00693-0.
^ Fanciullacci M, Sicuteri R, Alessandri M, Geppetti P (1995). „Buspirone, but not sumatriptan, induces miosis in humans: relevance for a serotoninergic pupil control”. Clinical Pharmacology and Therapeutics. 57 (3): 349—55. PMID 7697953. doi:10.1016/0009-9236(95)90161-2.
^ Cohn, JB; Rickels K (1989). „A pooled, double-blind comparison of the effects of buspirone, diazepam and placebo in women with chronic anxiety”. Curr Med Res Opin. 11 (5): 304—320. PMID 2649317. doi:10.1185/03007998909115213.
^ Cryan JF, Redmond AM, Kelly JP, Leonard BE (1997). „The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat.”. Eur Neuropsychopharmacol. 7 (2): 109—114. PMID 9169298. doi:10.1016/S0924-977X(96)00391-4.
^ Parks CL, Robinson PS, Sibille E, Shenk T, Toth M (1998). „Increased anxiety of mice lacking the serotonin1A receptor”. Proc Natl Acad Sci U S A. 195 (18): 10734—9. PMC 27964 . PMID 9724773. doi:10.1073/pnas.95.18.10734.
^ Kennett GA, Dourish CT, Curzon G (1987). „Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression”. Eur J Pharmacol. 134 (3): 265—74. PMID 2883013. doi:10.1016/0014-2999(87)90357-8.
^ Keller MB, Ruwe FJ, Janssens CJ, Sitsen JM, Jokinen R, Janczewski J (2005). „Relapse prevention with gepirone ER in outpatients with major depression”. Journal of Clinical Psychopharmacology. 25 (1): 79—84. PMID 15643103. doi:10.1097/01.jcp.0000150221.53877.d9. Архивирано из оригинала 05. 05. 2012. г. Приступљено 13. 07. 2011.
^ Cryan JF, Redmond AM, Kelly JP, Leonard BE (1997). „The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat”. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 7 (2): 109—14. PMID 9169298. doi:10.1016/S0924-977X(96)00391-4.
^ Invernizzi RW, Sacchetti G, Parini S, Acconcia S, Samanin R (2003). „Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT(1A) receptors.”. Br J Pharmacol. 139 (7): 1281—8. PMC 1573953 . PMID 12890707. doi:10.1038/sj.bjp.0705341.
^ de Paulis T. (2007). „Drug evaluation: PRX-00023, a selective 5-HT1A receptor agonist for depression.”. Curr Opin Investig Drugs. 8 (1): 78—86. PMID 17263189.
^ Stark, AD; et al. (2007). „Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT2A receptors: functional receptor-binding and in vivo electrophysiological studies.”. Psychopharmacology (Berl). 190 (3): 373—382. PMID 17242925. doi:10.1007/s00213-006-0621-y.
^ Vega, JAW; Mortimer AM; Tyson PJ (2003). „Conventional Antipsychotic Prescription in Unipolar Depression, I: An Audit and Recommendations for Practice”. The Journal of Clinical Psychiatry. Physicians Postgraduate Press. 64 (5): 568—574. ISSN 1555-2101. PMID 12755661. doi:10.4088/JCP.v64n0512. Архивирано из оригинала 17. 07. 2011. г. Приступљено 28. 05. 2009.
^ ^а ^б Van de Kar LD, Levy AD, Li Q, Brownfield MS (1998). „A comparison of the oxytocin and vasopressin responses to the 5-HT1A agonist and potential anxiolytic drug alnespirone (S-20499)”. Pharmacol Biochem Behav. 60 (3): 677—683. PMID 9678651. doi:10.1016/S0091-3057(98)00025-2.
^ Lorens SA, Van de Kar LD (1987). „Differential effects of serotonin (5-HT1A and 5-HT2) agonists and antagonists on renin and corticosterone secretion”. Neuroendocrinology. 45 (4): 305—310. PMID 2952898. doi:10.1159/000124754.
^ Koenig JI, Gudelsky GA, Meltzer HY (1987). „Stimulation of corticosterone and beta-endorphin secretion in the rat by selective 5-HT receptor subtype activation”. Eur J Pharmacol. 137 (1): 1—8. PMID 2956114. doi:10.1016/0014-2999(87)90175-0.
^ Pitchot W, Wauthy J, Legros JJ, Ansseau M (2004). „Hormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study”. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 14 (2): 151—5. PMID 15013031. doi:10.1016/S0924-977X(03)00108-1.
^ ^а ^б Thompson MR, Callaghan PD, Hunt GE, Cornish JL, McGregor IS (2007). „A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy")”. Neuroscience. 146 (2): 509—14. PMID 17383105. doi:10.1016/j.neuroscience.2007.02.032.
^ Pike VW, McCarron JA, Lammerstma AA, Hume SP, Poole K, Grasby PM, Malizia A, Cliffe IA, Fletcher A, Bench CJ (1995). „First delineation of 5-HT_1A receptors in human brain with PET and [¹¹C]WAY-100635”. Eur. J. Pharmacol. 283 (1–3): R1—3. PMID 7498295. doi:10.1016/0014-2999(95)00438-Q.
^ Price JC, Kelley DE, Ryan CM, Meltzer CC, Drevets WC, Mathis CA, Mazumdar S, Reynolds CF (2002). „Evidence of increased serotonin-1A receptor binding in type 2 diabetes: a positron emission tomography study”. Brain Res. 927 (1): 97—103. PMID 11814436. doi:10.1016/S0006-8993(01)03297-8.
^ Borg J, Andrée B, Soderstrom H, Farde L (2003). „The serotonin system and spiritual experiences”. Am J Psychiatry. 160 (11): 1965—9. PMID 14594742. doi:10.1176/appi.ajp.160.11.1965.
^ Burnet PW, Eastwood SL, Harrison PJ (1997). „[³H]WAY-100635 for 5-HT_1A receptor autoradiography in human brain: a comparison with [³H]8-OH-DPAT and demonstration of increased binding in the frontal cortex in schizophrenia”. Neurochem. Int. 30 (6): 565—574. PMID 9152998. doi:10.1016/S0197-0186(96)00124-6.
^ ^а ^б ^в Drago A, Ronchi DD, Serretti A (2008). „5-HT_1A gene variants and psychiatric disorders: a review of current literature and selection of SNPs for future studies”. Int. J. Neuropsychopharmacol. 11 (5): 701—21. PMID 18047755. doi:10.1017/S1461145707008218.
^ Wu S, Comings DE (1999). „A common C-1018G polymorphism in the human 5-HT_1A receptor gene”. Psychiatr. Genet. 9 (2): 105—6. PMID 10412191. doi:10.1097/00041444-199906000-00010.
^ Anttila S; Huuhka K; Huuhka M; Rontu R; Hurme M; Leinonen E; et al. (2007). „Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression”. J Neural Transm. 114 (8): 1065—8. PMID 17401528. doi:10.1007/s00702-007-0705-9.
^ Guiard BP; David DJ; Deltheil T; Chenu F; Le Maître E; Renoir T; et al. (2008). „Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype”. Int J Neuropsychopharmacol. 11 (1): 79—92. PMID 17559709. doi:10.1017/S1461145707007857.
^ Salim, Kamran; Fenton Tim; et al. (2002). „Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation”. J. Biol. Chem. 277 (18): 15482—5. PMID 11854302. doi:10.1074/jbc.M201539200.

Literatura

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Van Oekelen D, Luyten WH, Leysen JE (2003). „5-HT2A and 5-HT2C receptors and their atypical regulation properties”. Life Sci. 72 (22): 2429—49. PMID 12650852. doi:10.1016/S0024-3205(03)00141-3.
Lesch KP, Gutknecht L (2005). „Focus on The 5-HT1A receptor: emerging role of a gene regulatory variant in psychopathology and pharmacogenetics”. Int. J. Neuropsychopharmacol. 7 (4): 381—5. PMID 15683551. doi:10.1017/S1461145704004845.
Kalipatnapu S, Chattopadhyay A (2006). „Membrane protein solubilization: recent advances and challenges in solubilization of serotonin1A receptors”. IUBMB Life. 57 (7): 505—12. PMID 16081372. doi:10.1080/15216540500167237.
Varrault A, Bockaert J, Waeber C (1992). „Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis”. Mol. Biol. Cell. 3 (9): 961—9. PMC 275657 . PMID 1330092.
Levy FO; Gudermann T; Perez-Reyes E; et al. (1992). „Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype”. J. Biol. Chem. 267 (11): 7553—62. PMID 1559993.
Melmer G; Sherrington R; Mankoo B; et al. (1992). „A cosmid clone for the 5HT1A receptor (HTR1A) reveals a TaqI RFLP that shows tight linkage to dna loci D5S6, D5S39, and D5S76”. Genomics. 11 (3): 767—9. PMID 1685484. doi:10.1016/0888-7543(91)90088-V.
Parks CL, Chang LS, Shenk T (1992). „A polymerase chain reaction mediated by a single primer: cloning of genomic sequences adjacent to a serotonin receptor protein coding region”. Nucleic Acids Res. 19 (25): 7155—60. PMC 332551 . PMID 1766875. doi:10.1093/nar/19.25.7155.
Gilliam TC; Freimer NB; Kaufmann CA; et al. (1990). „Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia”. Genomics. 5 (4): 940—4. PMID 2591972. doi:10.1016/0888-7543(89)90138-9.
Kobilka BK; Frielle T; Collins S; et al. (1987). „An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins”. Nature. 329 (6134): 75—9. PMID 3041227. doi:10.1038/329075a0.
Fargin A; Raymond JR; Lohse MJ; et al. (1988). „The genomic clone G-21, which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor”. Nature. 335 (6188): 358—60. PMID 3138543. doi:10.1038/335358a0.
Nakhai B, Nielsen DA, Linnoila M, Goldman D (1995). „Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28”. Biochem. Biophys. Res. Commun. 210 (2): 530—6. PMID 7755630. doi:10.1006/bbrc.1995.1692.
Aune TM; McGrath KM; Sarr T; et al. (1993). „Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine”. J. Immunol. 151 (3): 1175—83. PMID 8393041.
Parks CL, Shenk T (1996). „The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1”. J. Biol. Chem. 271 (8): 4417—30. PMID 8626793. doi:10.1074/jbc.271.8.4417.
Stockmeier CA; Shapiro LA; Dilley GE; et al. (1998). „Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity”. J. Neurosci. 18 (18): 7394—401. PMID 9736659.
Kawanishi Y; Harada S; Tachikawa H; et al. (1998). „Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia”. Am. J. Med. Genet. 81 (5): 434—9. PMID 9754630. doi:10.1002/(SICI)1096-8628(19980907)81:5<434::AID-AJMG13>3.0.CO;2-D.
Salim K; Fenton T; Bacha J; et al. (2002). „Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation”. J. Biol. Chem. 277 (18): 15482—5. PMID 11854302. doi:10.1074/jbc.M201539200.

Spoljašnje veze

„5-HT_1A”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 02. 09. 2012. г. Приступљено 12. 07. 2011.

[pmid2591972-1] Gilliam TC, Freimer NB, Kaufmann CA, Powchik PP, Bassett AS, Bengtsson U, Wasmuth JJ (1989). „Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia”. Genomics. 5 (4): 940—4. PMID 2591972. doi:10.1016/0888-7543(89)90138-9.

[entrez-2] „Entrez Gene: HTR1A 5-hydroxytryptamine (serotonin) receptor 1A”.

[pmid9935065-3] Ito H, Halldin C, Farde L (1999). „Localization of 5-HT1A receptors in the living human brain using [carbonyl-11C]WAY-100635: PET with anatomic standardization technique.”. J Nucl Med. 40 (1): 102—9. PMID 9935065.

[urlSerotonin_Receptor_Subtypes_and_Ligands-4] Glennon RA, Dukat M, Westkaemper RB (1. 1. 2000). „Serotonin Receptor Subtypes and Ligands”. American College of Neurophyscopharmacology. Приступљено 11. 4. 2008.

[pmid18761712-5] Almeida J, Mengod G (2008). „Serotonin 1A receptors in human and monkey prefrontal cortex are mainly expressed in pyramidal neurons and in a GABAergic interneuron subpopulation: implications for schizophrenia and its treatment.”. J Neurochem. 107 (2): 488—496. PMID 18761712. doi:10.1111/j.1471-4159.2008.05649.x.

[pmid1819150-6] а ^б Dabiré H. (1991). „Central 5-hydroxytryptamine (5-HT) receptors in blood pressure regulation.”. Therapie. 46 (6): 421—9. PMID 1819150.

[pmid1855130-7] Ramage AG (1991). „The mechanism of the sympathoinhibitory action of urapidil: role of 5-HT1A receptors”. Br. J. Pharmacol. 102 (4): 998—1002. PMC 1917978 . PMID 1855130.

[pmid2569265-8] Kolassa N, Beller KD, Sanders KH (1989). „Involvement of brain 5-HT1A receptors in the hypotensive response to urapidil.”. Am J Cardiol. 64 (7): 7D—10D. PMID 2569265. doi:10.1016/0002-9149(89)90688-7.

[pmid16455061-9] Ootsuka Y, Blessing WW (2006). „Activation of 5-HT1A receptors in rostral medullary raphé inhibits cutaneous vasoconstriction elicited by cold exposure in rabbits.”. Brain Res. 1073-1074: 252—61. PMID 16455061. doi:10.1016/j.brainres.2005.12.031.

[pmid17702902-10] Rusyniak DE, Zaretskaia MV, Zaretsky DV, DiMicco JA (2007). „3,4-Methylenedioxymethamphetamine- and 8-hydroxy-2-di-n-propylamino-tetralin-induced hypothermia: role and location of 5-hydroxytryptamine 1A receptors.”. J Pharmacol Exp Ther. 323 (2): 477—487. PMID 17702902. doi:10.1124/jpet.107.126169.

[pmid15087245-11] Yu Y, Ramage AG, Koss MC (2004). „Pharmacological studies of 8-OH-DPAT-induced pupillary dilation in anesthetized rats.”. Eur J Pharmacol. 489 (3): 207—213. PMID 15087245. doi:10.1016/j.ejphar.2004.03.007.

[pmid8982715-12] Prow MR, Martin KF, Heal DJ (1996). „8-OH-DPAT-induced mydriasis in mice: a pharmacological characterisation”. Eur J Pharmacol. 317 (1): 21—8. PMID 8982715. doi:10.1016/S0014-2999(96)00693-0.

[pmid7697953-13] Fanciullacci M, Sicuteri R, Alessandri M, Geppetti P (1995). „Buspirone, but not sumatriptan, induces miosis in humans: relevance for a serotoninergic pupil control”. Clinical Pharmacology and Therapeutics. 57 (3): 349—55. PMID 7697953. doi:10.1016/0009-9236(95)90161-2.

[14] Cohn, JB; Rickels K (1989). „A pooled, double-blind comparison of the effects of buspirone, diazepam and placebo in women with chronic anxiety”. Curr Med Res Opin. 11 (5): 304—320. PMID 2649317. doi:10.1185/03007998909115213.

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