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Uvojiti receptor 1
Uvojiti receptor 1
Identifikatori
Simboli	FZD1; DKFZp564G072; FLJ95923
Vanjski ID	OMIM: 603408 MGI: 1196625 HomoloGene: 20750 IUPHAR: FZD1 GeneCards: FZD1 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G protein spregnutog receptora; • receptorsko vezivanje; • proteinsko vezivanje; • Wnt proteinsko vezivanje; • vezivanje PDZ domena;
Celularna komponenta	• citoplazma; • ćelijska površina; • integralno sa membranom; • sinaptosom; • membrana neuronske projekcije;
Biološki proces	• pozitivna regulacija proteinske fosforilacije; • razvoj vaskulature; • morfogeneza odlivnog trakta; • signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	8321
Ensembl	ENSG00000157240
UniProt	Q9UP38
RefSeq (mRNA)	NM_003505.1
RefSeq (protein)	NP_003496.1
Lokacija (UCSC)	Chr 7:; 90.89 - 90.9 Mb
PubMed pretraga	[1]

Uvojiti-1 je protein koji je kod ljudi kodiran FZD1 genom.^[1]^[2]

Članovi familije 'uvojitih' proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD1 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. FZD1 transkript je izražen u različitim tkivima.^[2]

Reference

^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (1998). „Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7”. Biochem Biophys Res Commun. 252 (1): 117—22. PMID 9813155. doi:10.1006/bbrc.1998.9607.
^ ^а ^б „Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)”.

Literatura

Tanaka S; Akiyoshi T; Mori M; et al. (1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164—9. PMC 21479 . PMID 9707618. doi:10.1073/pnas.95.17.10164.
Gazit A; Yaniv A; Bafico A; et al. (1999). „Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.”. Oncogene. 18 (44): 5959—66. PMID 10557084. doi:10.1038/sj.onc.1202985.
DeCostanzo AJ, Huang XP, Wang HY, Malbon CC (2002). „The Frizzled-1/(beta(2))-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor.”. Naunyn Schmiedebergs Arch. Pharmacol. 365 (5): 341—8. PMID 12012019. doi:10.1007/s00210-002-0540-3.
Hering H, Sheng M (2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.”. FEBS Lett. 521 (1–3): 185—9. PMID 12067714. doi:10.1016/S0014-5793(02)02831-4.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Scherer SW; Cheung J; MacDonald JR; et al. (2003). „Human chromosome 7: DNA sequence and biology”. Science. 300 (5620): 767—72. PMC 2882961 . PMID 12690205. doi:10.1126/science.1083423.
Hillier LW; Fulton RS; Fulton LA; et al. (2003). „The DNA sequence of human chromosome 7”. Nature. 424 (6945): 157—64. PMID 12853948. doi:10.1038/nature01782.
Zilberberg A, Yaniv A, Gazit A (2004). „The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway”. J. Biol. Chem. 279 (17): 17535—42. PMID 14739301. doi:10.1074/jbc.M311292200.
Wu J, Klein TJ, Mlodzik M (2006). „Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity”. PLoS Biol. 2 (7): E158. PMC 449784 . PMID 15252441. doi:10.1371/journal.pbio.0020158.
Omoto S; Hayashi T; Kitahara K; et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”. Ophthalmic Genet. 25 (2): 81—90. PMID 15370539. doi:10.1080/13816810490514270.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Yang L; Yamasaki K; Shirakata Y; et al. (2006). „Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes”. J. Dermatol. Sci. 42 (2): 111—9. PMID 16442268. doi:10.1016/j.jdermsci.2005.12.011.

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Uvojiti receptori

Spoljašnje veze

„Frizzled Receptors: FZD₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.