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Bradikininski receptor B1
Bradikininski receptor B1
Identifikatori
Simboli	BDKRB1; B1BKR; B1R; BKB1R; BKR1; BRADYB1
Vanjski ID	OMIM: 600337 MGI: 88144 HomoloGene: 570 IUPHAR: B1 GeneCards: BDKRB1 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost; • aktivnost bradikininskog receptora;
Celularna komponenta	• endoplazmatični retikulum; • ćelijska membrana; • integralno sa ćelijskom membranom;
Biološki proces	• inflamatorni respons; • prenos signala; • signalni put G-protein spregnutog receptora; • elevacija koncentracije citosolnih jona kalcijuma;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	623
Ensembl	ENSG00000100739
UniProt	P46663
RefSeq (mRNA)	NM_000710
RefSeq (protein)	NP_000701
Lokacija (UCSC)	Chr 14:; 95.8 - 95.8 Mb
PubMed pretraga	[1]

Bradikininski receptor B1 (B₁) је G-protein spregnuti receptor kodiran BDKRB1 genom kod ljudi. Njegov principalni ligand je bradikinin, peptid sa 9 aminokiselina koji se formira u patofiziološkim uslovima kao što je inflamacija, trauma, opekotine, šok, i alergija. B₁ receptor je jedan od dva G protein-spregnuta receptora za koje je utvrđeno da vezuju bradikinin i posreduju response na te patofiziološke uslove.

B₁ protein se sintetiše de novo nakon povrede tkiva. Njegovo vezivanje za receptor dovodi do povećanja citosolne koncentracije jona kalcijuma, što ultimatno dovodi do hroničnog i akutnog inflamatornog responsa.^[1]

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Bradikininski receptor

Literatura

^ „Entrez Gene: BDKRB1 bradykinin receptor B1”.

Dodatna literatura

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Menke JG; Borkowski JA; Bierilo KK; et al. (1994). „Expression cloning of a human B1 bradykinin receptor.”. J. Biol. Chem. 269 (34): 21583—6. PMID 8063797.
Yang X, Polgar P (1996). „Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions.”. Biochem. Biophys. Res. Commun. 222 (3): 718—25. PMID 8651911. doi:10.1006/bbrc.1996.0810.
Bachvarov DR; Hess JF; Menke JG; et al. (1996). „Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1).”. Genomics. 33 (3): 374—81. PMID 8660997. doi:10.1006/geno.1996.0213.
Chai KX; Ni A; Wang D; et al. (1996). „Genomic DNA sequence, expression, and chromosomal localization of the human B1 bradykinin receptor gene BDKRB1.”. Genomics. 31 (1): 51—7. PMID 8808279. doi:10.1006/geno.1996.0008.
Leeb T, Mathis SA, Leeb-Lundberg LM (1997). „The sixth transmembrane domains of the human B1 and B2 bradykinin receptors are structurally compatible and involved in discriminating between subtype-selective agonists.”. J. Biol. Chem. 272 (1): 311—7. PMID 8995263. doi:10.1074/jbc.272.1.311.
Blaukat A; Herzer K; Schroeder C; et al. (1999). „Overexpression and functional characterization of kinin receptors reveal subtype-specific phosphorylation.”. Biochemistry. 38 (4): 1300—9. PMID 9930991. doi:10.1021/bi981727r.
Cassano G, Susca F, Lippe C, Guanti G (1999). „Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts.”. Gen. Pharmacol. 32 (2): 239—44. PMID 10188626. doi:10.1016/S0306-3623(98)00275-4.
Zhou X; Prado GN; Chai M; et al. (2000). „Posttranscriptional destabilization of the bradykinin B1 receptor messenger RNA: cloning and functional characterization of the 3'-untranslated region.”. Mol. Cell Biol. Res. Commun. 1 (1): 29—35. PMID 10329474. doi:10.1006/mcbr.1999.0105.
Jones C; Phillips E; Davis C; et al. (1999). „Molecular characterisation of cloned bradykinin B1 receptors from rat and human.”. Eur. J. Pharmacol. 374 (3): 423—33. PMID 10422787. doi:10.1016/S0014-2999(99)00315-5.
Sjuve R, Boels PJ, Uvelius B, Arner A (2000). „Up-regulation of bradykinin response in rat and human bladder smooth muscle.”. J. Urol. 164 (5): 1757—63. PMID 11025765. doi:10.1016/S0022-5347(05)67102-9.
Sawant S, Snyman C, Bhoola K (2002). „Comparison of tissue kallikrein and kinin receptor expression in gastric ulcers and neoplasms.”. Int. Immunopharmacol. 1 (12): 2063—80. PMID 11710536. doi:10.1016/S1567-5769(01)00118-7.
Ignjatovic T; Tan F; Brovkovych V; et al. (2002). „Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor.”. J. Biol. Chem. 277 (19): 16847—52. PMID 11880373. doi:10.1074/jbc.M200355200.
Newton R; Eddleston J; Haddad el-B; et al. (2002). „Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone.”. Eur. J. Pharmacol. 441 (3): 193—202. PMID 12063092. doi:10.1016/S0014-2999(01)01624-7.
Kang DS, Leeb-Lundberg LM (2002). „Negative and positive regulatory epitopes in the C-terminal domains of the human B1 and B2 bradykinin receptor subtypes determine receptor coupling efficacy to G(q/11)-mediated [correction of G(9/11)-mediated] phospholipase Cbeta activity.”. Mol. Pharmacol. 62 (2): 281—8. PMID 12130679. doi:10.1124/mol.62.2.281.
Christiansen SC; Eddleston J; Woessner KM; et al. (2002). „Up-regulation of functional kinin B1 receptors in allergic airway inflammation.”. J. Immunol. 169 (4): 2054—60. PMID 12165532.
Lamb ME; Zhang C; Shea T; et al. (2003). „Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells.”. Biochemistry. 41 (48): 14340—7. PMID 12450400. doi:10.1021/bi020231d.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Kang DS, Ryberg K, Mörgelin M, Leeb-Lundberg LM (2004). „Spontaneous formation of a proteolytic B1 and B2 bradykinin receptor complex with enhanced signaling capacity.”. J. Biol. Chem. 279 (21): 22102—7. PMID 15033977. doi:10.1074/jbc.M402572200.
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Spoljašnje veze

„Bradykinin Receptors: B₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.