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Melanokortin 5 receptor
Melanokortin 5 receptor
Identifikatori
Simboli	MC5R;
Vanjski ID	OMIM: 600042 MGI: 99420 HomoloGene: 4321 IUPHAR: MC5 GeneCards: MC5R Gene
Ontologija gena
Molekularna funkcija	• rodopsinu-slična receptorska aktivnost; • receptorska aktivnost; • receptorska aktivnost melanokortina;
Celularna komponenta	• integralno sa membranom plazme; • membrana;
Biološki proces	• prenos signala; • G-protein signalizacija, spregnuta sa cikličnim nukleotidnim drugim glasnikom;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	4161
Ensembl	ENSG00000176136
UniProt	P33032
RefSeq (mRNA)	NM_005913
RefSeq (protein)	NP_005904
Lokacija (UCSC)	Chr 18:; 13.82 - 13.82 Mb
PubMed pretraga	[1]

Melanokortin receptor 5 je protein koji je kod ljudi kodiran MC5R genom.^[1]^[2] On je lociran na hromozomu 18 u ljudskom genomu.^[2] Kad se melanokortin 5 receptor onestposobljen kod transgenetskih miševa, indukuju se poremećaji rada njihovih eksokrinih žlezda, što rezultuje u umanjenoj produkciji lojnih žlezdi.^[3]

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Melanokortin receptor

Reference

^ Chhajlani V, Muceniece R, Wikberg JE (1993). „Molecular cloning of a novel human melanocortin receptor”. Biochem Biophys Res Commun. 195 (2): 866—73. PMID 8396929. doi:10.1006/bbrc.1993.2125.
^ ^а ^б „Entrez Gene: MC5R melanocortin 5 receptor”.
^ Thiboutot, Diane; Sivarajah, Aruntha; et al. (2000). „The Melanocortin 5 Receptor is Expressed in Human Sebaceous Glands and Rat Preputial Cells”. Journal of Investigative Dermatology. 115 (4): 614—619. PMID 10998132. doi:10.1046/j.1523-1747.2000.00094.x. Приступљено 04. 01. 2008.

Literatura

Fathi Z, Iben LG, Parker EM (1995). „Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype.”. Neurochem. Res. 20 (1): 107—13. PMID 7739752. doi:10.1007/BF00995160.
Chowdhary BP, Gustavsson I, Wikberg JE, Chhajlani V (1994). „Localization of the human melanocortin-5 receptor gene (MC5R) to chromosome band 18p11.2 by fluorescence in situ hybridization.”. Cytogenet. Cell Genet. 68 (1-2): 79—81. PMID 7956366. doi:10.1159/000133895.
Griffon N; Mignon V; Facchinetti P; et al. (1994). „Molecular cloning and characterization of the rat fifth melanocortin receptor.”. Biochem. Biophys. Res. Commun. 200 (2): 1007—14. PMID 8179577. doi:10.1006/bbrc.1994.1550.
Gantz I; Shimoto Y; Konda Y; et al. (1994). „Molecular cloning, expression, and characterization of a fifth melanocortin receptor.”. Biochem. Biophys. Res. Commun. 200 (3): 1214—20. PMID 8185570. doi:10.1006/bbrc.1994.1580.
Chhajlani V (1997). „Distribution of cDNA for melanocortin receptor subtypes in human tissues.”. Biochem. Mol. Biol. Int. 38 (1): 73—80. PMID 8932521.
Yang YK; Ollmann MM; Wilson BD; et al. (1997). „Effects of recombinant agouti-signaling protein on melanocortin action.”. Mol. Endocrinol. 11 (3): 274—80. PMID 9058374. doi:10.1210/me.11.3.274.
Frändberg PA, Xu X, Chhajlani V (1997). „Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH.”. Biochem. Biophys. Res. Commun. 236 (2): 489—92. PMID 9240466. doi:10.1006/bbrc.1997.6994.
Yang YK; Thompson DA; Dickinson CJ; et al. (1999). „Characterization of Agouti-related protein binding to melanocortin receptors.”. Mol. Endocrinol. 13 (1): 148—55. PMID 9892020. doi:10.1210/me.13.1.148.
Hatta N; Dixon C; Ray AJ; et al. (2001). „Expression, candidate gene, and population studies of the melanocortin 5 receptor.”. J. Invest. Dermatol. 116 (4): 564—70. PMID 11286624. doi:10.1046/j.0022-202x.2001.01286.x.
Bednarek MA; MacNeil T; Kalyani RN; et al. (2001). „Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro.”. J. Med. Chem. 44 (22): 3665—72. PMID 11606131. doi:10.1021/jm010165y.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Lapinsh M; Veiksina S; Uhlén S; et al. (2005). „Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes.”. Mol. Pharmacol. 67 (1): 50—9. PMID 15470082. doi:10.1124/mol.104.002857.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Lohoff FW, Berrettini WH (2006). „Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder.”. Psychiatr. Genet. 15 (4): 255—8. PMID 16314755. doi:10.1097/00041444-200512000-00007.
Grieco P; Cai M; Han G; et al. (2007). „Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.”. Peptides. 28 (6): 1191—6. PMC 1955225 . PMID 17482720. doi:10.1016/j.peptides.2007.02.012.
„Melanocortin Receptors: MC₅”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 14. 07. 2014. г.

[pmid8396929-1] Chhajlani V, Muceniece R, Wikberg JE (1993). „Molecular cloning of a novel human melanocortin receptor”. Biochem Biophys Res Commun. 195 (2): 866—73. PMID 8396929. doi:10.1006/bbrc.1993.2125.

[entrez-2] а ^б „Entrez Gene: MC5R melanocortin 5 receptor”.

[3] Thiboutot, Diane; Sivarajah, Aruntha; et al. (2000). „The Melanocortin 5 Receptor is Expressed in Human Sebaceous Glands and Rat Preputial Cells”. Journal of Investigative Dermatology. 115 (4): 614—619. PMID 10998132. doi:10.1046/j.1523-1747.2000.00094.x. Приступљено 04. 01. 2008.

[1]

[2]

[3]

Melanokortinski 5 receptor

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Reference

Literatura