Melatoninski receptor 1A

Melatoninski receptor 1A
Identifikatori
Simboli MTNR1A; MEL-1A-R; MT1
Vanjski ID OMIM: 600665 MGI: 102967 HomoloGene: 21207 IUPHAR: MT1 GeneCards: MTNR1A Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 4543 17773
Ensembl ENSG00000168412 ENSMUSG00000054764
UniProt P48039 Q61184
RefSeq (mRNA) NM_005958.3 NM_008639.2
RefSeq (protein) NP_005949.1 NP_032665.1
Lokacija (UCSC) Chr 4:
187.35 - 187.48 Mb		 Chr 8:
46.15 - 46.17 Mb
PubMed pretraga [1] [2]

Melatoninski receptor tip 1A je protein koji je kod ljudi kodiran MTNR1A genom.[1][2]

MT1 protein je jedan od dva receptora sa visokim afinitetom za melatonin, koji je primarni hormon epifize. Ovaj receptor je G protein spregnuti 7-transmembranski receptor koji je odgovoran za dejstvo melatonina na sisarski cirkadijanski ritam i reproduktivne promene na koje utiče dužina dana. Ovaj receptor je integralni membranski protein koji je lociran u dva specifična moždana regiona. Hipotalamusno suprahiazmatično jedro učestvuju u cirkadijanskom ritmu, dok je hipofizni pars tuberalis odgovoran za reproduktivne efekte melatonina.[2]

Vidi još

Reference

  1. ^ Slaugenhaupt SA, Roca AL, Liebert CB, Altherr MR, Gusella JF, Reppert SM (1995). „Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)”. Genomics. 27 (2): 355—7. PMID 7558006. doi:10.1006/geno.1995.1056. 
  2. ^ а б „Entrez Gene: MTNR1A melatonin receptor 1A”. 

Literatura

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  • Witt-Enderby PA, Dubocovich ML (1996). „Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells”. Mol. Pharmacol. 50 (1): 166—74. PMID 8700109. 
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  • Ayoub MA; Couturier C; Lucas-Meunier E; et al. (2002). „Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer”. J. Biol. Chem. 277 (24): 21522—8. PMID 11940583. doi:10.1074/jbc.M200729200. 
  • Yuan L; Collins AR; Dai J; et al. (2003). „MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells”. Mol. Cell. Endocrinol. 192 (1–2): 147—56. PMID 12088876. doi:10.1016/S0303-7207(02)00029-1. 
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  • Morcuende JA; Minhas R; Dolan L; et al. (2004). „Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis”. Spine. 28 (17): 2025—8; discussion 2029. PMID 12973153. doi:10.1097/01.BRS.0000083235.74593.49. 
  • Aust S; Thalhammer T; Humpeler S; et al. (2004). „The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia”. J. Pineal Res. 36 (1): 43—8. PMID 14675129. doi:10.1046/j.1600-079X.2003.00095.x. 

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