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Somatostatinski receptor 4
Somatostatinski receptor 4
Identifikatori
Simboli	SSTR4;
Vanjski ID	OMIM: 182454 MGI: 105372 HomoloGene: 20286 IUPHAR: sst4 GeneCards: SSTR4 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost; • aktivnost somatostatinskog receptora; • aktivnost melanin-koncentrujućeg hormonskog receptora;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• prenos signala; • G-proteinska signalizacija, spregnuta sa ciklično nukleotidnim sekundarnim glasnikom; • neuropeptidni signalni put; • negativna regulacija ćelijske proliferacije;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	6754
Ensembl	ENSG00000132671
UniProt	P31391
RefSeq (mRNA)	NM_001052
RefSeq (protein)	NP_001043
Lokacija (UCSC)	Chr 20:; 22.96 - 22.97 Mb
PubMed pretraga	[1]

Somatostatinski receptor tip 4 je protein koji je kod čoveka kodiran SSTR4 genom.^[1]^[2]

Somatostatin deluje na mnogim lokacijama i inhibira oslobađanje hormona i drugih sekretornih proteina. Biološki efekti somatostatina su posredovani familijom G protein-spregnutih receptora čije izražavanje je specifično za pojedina tkiva. SSTR4 u znatnoj meri izražen u mozgu fetusa i odraslih osoba, kao i u plućima.^[2]

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Somatostatinski receptor

Literatura

^ Rohrer L, Raulf F, Bruns C, Buettner R, Hofstaedter F, Schule R (1993). „Cloning and characterization of a fourth human somatostatin receptor”. Proc Natl Acad Sci U S A. 90 (9): 4196—200. PMC 46473 . PMID 8483934. doi:10.1073/pnas.90.9.4196.
^ ^а ^б „Entrez Gene: SSTR4 somatostatin receptor 4”.

Dodatna literatura

Patel YC (1999). „Somatostatin and its receptor family.”. Frontiers in neuroendocrinology. 20 (3): 157—98. PMID 10433861. doi:10.1006/frne.1999.0183.
Yamada Y; Post SR; Wang K; et al. (1992). „Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.”. Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251—5. PMC 48214 . PMID 1346068. doi:10.1073/pnas.89.1.251.
Demchyshyn LL; Srikant CB; Sunahara RK; et al. (1993). „Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20.”. Mol. Pharmacol. 43 (6): 894—901. PMID 8100352.
Yasuda K; Espinosa R; Davis EM; et al. (1993). „Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2.”. Genomics. 17 (3): 785—6. PMID 8244401. doi:10.1006/geno.1993.1410.
Yamada Y; Kagimoto S; Kubota A; et al. (1993). „Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype.”. Biochem. Biophys. Res. Commun. 195 (2): 844—52. PMID 8373420. doi:10.1006/bbrc.1993.2122.
Kaupmann K; Bruns C; Hoyer D; et al. (1993). „Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain.”. FEBS Lett. 331 (1-2): 53—9. PMID 8405411. doi:10.1016/0014-5793(93)80296-7.
Yamada Y; Stoffel M; Espinosa R; et al. (1993). „Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms.”. Genomics. 15 (2): 449—52. PMID 8449518. doi:10.1006/geno.1993.1088.
Xu Y, Song J, Bruno JF, Berelowitz M (1993). „Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4.”. Biochem. Biophys. Res. Commun. 193 (2): 648—52. PMID 8512564. doi:10.1006/bbrc.1993.1673.
Fukusumi S; Kitada C; Takekawa S; et al. (1997). „Identification and characterization of a novel human cortistatin-like peptide.”. Biochem. Biophys. Res. Commun. 232 (1): 157—63. PMID 9125122. doi:10.1006/bbrc.1997.6252.
de Lecea L; Ruiz-Lozano P; Danielson PE; et al. (1997). „Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin.”. Genomics. 42 (3): 499—506. PMID 9205124. doi:10.1006/geno.1997.4763.
Jaïs P; Terris B; Ruszniewski P; et al. (1997). „Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.”. Eur. J. Clin. Invest. 27 (8): 639—44. PMID 9279525. doi:10.1046/j.1365-2362.1997.1740719.x.
Sharma K, Patel YC, Srikant CB (1999). „C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.”. Mol. Endocrinol. 13 (1): 82—90. PMID 9892014. doi:10.1210/me.13.1.82.
Forssell-Aronsson EB; Nilsson O; Bejegård SA; et al. (2000). „111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors.”. J. Nucl. Med. 41 (4): 636—42. PMID 10768564.
Zatelli MC; Tagliati F; Taylor JE; et al. (2001). „Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt.”. J. Clin. Endocrinol. Metab. 86 (5): 2161—9. PMID 11344221. doi:10.1210/jc.86.5.2161.
Talme T; Ivanoff J; Hägglund M; et al. (2001). „Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3.”. Clin. Exp. Immunol. 125 (1): 71—9. PMC 1906108 . PMID 11472428. doi:10.1046/j.1365-2249.2001.01577.x.
Pasquali D; Notaro A; Esposito D; et al. (2002). „[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]”. Minerva Endocrinol. 26 (3): 175—9. PMID 11753241.
Deloukas P; Matthews LH; Ashurst J; et al. (2002). „The DNA sequence and comparative analysis of human chromosome 20.”. Nature. 414 (6866): 865—71. PMID 11780052. doi:10.1038/414865a.
Papotti M; Bongiovanni M; Volante M; et al. (2002). „Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis.”. Virchows Arch. 440 (5): 461—75. PMID 12021920. doi:10.1007/s00428-002-0609-x.

Spoljašnje veze

„Somatostatin Receptors: sst₄”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.
somatostatin+receptor+subtype-4 на US National Library of Medicine Medical Subject Headings (MeSH)

[pmid8483934-1] Rohrer L, Raulf F, Bruns C, Buettner R, Hofstaedter F, Schule R (1993). „Cloning and characterization of a fourth human somatostatin receptor”. Proc Natl Acad Sci U S A. 90 (9): 4196—200. PMC 46473 . PMID 8483934. doi:10.1073/pnas.90.9.4196.

[entrez-2] а ^б „Entrez Gene: SSTR4 somatostatin receptor 4”.

[1]

[2]

Somatostatinski receptor 4

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Literatura

Dodatna literatura

Spoljašnje veze