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Receptor ukusa tip 2 član 16
Receptor ukusa tip 2 član 16
Identifikatori
Simboli	TAS2R16; T2R16
Vanjski ID	OMIM: 604867 MGI: 2681247 HomoloGene: 9660 IUPHAR: GeneCards: TAS2R16 Gene
Ontologija gena
Molekularna funkcija	• aktivnost receptora ukusa;
Celularna komponenta	• integralno sa membranom;
Biološki proces	• signalni put G-protein spregnutog receptora; • hemosensorno ponašanje; • detekcija hemijskog stimulusa koji učestvuje u senzornoj percepciji ukusa;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	50833
Ensembl	ENSG00000128519
UniProt	Q9NYV7
RefSeq (mRNA)	NM_016945.2
RefSeq (protein)	NP_058641.1
Lokacija (UCSC)	Chr 7:; 122.63 - 122.64 Mb
PubMed pretraga	[1]

Receptor ukusa tip 2 član 16 je protein koji je kod ljudi kodiran TAS2R16 genom.^[1]^[2]

Varijante ovog gena su povezane sa povećanim rizikom od alkoholne zavisnosti.^[3]

TAS2R16 gen je lociran na dugačkoj (q) ruci hromozoma 7 u poziciji 31.1 - 31.3, od baznog para 122.228.764 do baznog para 122.229.639.

Reference

^ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002). „The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides”. Nat Genet. 32 (3): 397—401. PMID 12379855. doi:10.1038/ng1014.
^ Drewnowski A (2001). „The science and complexity of bitter taste”. Nutr Rev. 59 (6): 163—9. PMID 11444592. doi:10.1111/j.1753-4887.2001.tb07007.x.
^ Hinrichs AL; Wang JC; Bufe B; et al. (2006). „Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence”. Am. J. Hum. Genet. 78 (1): 103—11. PMC 1380207 . PMID 16385453. doi:10.1086/499253.

Literatura

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Bufe B; Hofmann T; Krautwurst D; et al. (2002). „The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.”. Nat. Genet. 32 (3): 397—401. PMID 12379855. doi:10.1038/ng1014.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
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Mueller KL; Hoon MA; Erlenbach I; et al. (2005). „The receptors and coding logic for bitter taste.”. Nature. 434 (7030): 225—9. PMID 15759003. doi:10.1038/nature03352.
Hinrichs AL; Wang JC; Bufe B; et al. (2006). „Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence.”. Am. J. Hum. Genet. 78 (1): 103—11. PMC 1380207 . PMID 16385453. doi:10.1086/499253.
Behrens M; Bartelt J; Reichling C; et al. (2006). „Members of RTP and REEP gene families influence functional bitter taste receptor expression.”. J. Biol. Chem. 281 (29): 20650—9. PMID 16720576. doi:10.1074/jbc.M513637200.