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Receptor gastričnog inhibitornog polipeptida‎
Receptor gastričnog inhibitornog polipeptida‎
Dostupne strukture
	2QKH
Identifikatori
Simboli	GIPR; PGQTL2
Vanjski ID	OMIM: 137241 MGI: 1352753 HomoloGene: 20081 IUPHAR: GIP GeneCards: GIPR Gene
Ontologija gena
Molekularna funkcija	• aktivnost transmembranskog signalnog receptora; • aktivnost gastričnog inhibitornog peptidnog receptora; • vezivanje peptidnog hormona;
Celularna komponenta	• ćelijska membrana; • integralno sa membranom;
Biološki proces	• signalni put desenzitizacije G-protein spregnutog receptora; • formiranje prekursorskih metabolita i energije; • signalni put ćelijskog receptora;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	2696
Ensembl	ENSG00000010310
UniProt	P48546
RefSeq (mRNA)	NM_000164.2
RefSeq (protein)	NP_000155.1
Lokacija (UCSC)	Chr 19:; 46.17 - 46.19 Mb
PubMed pretraga	[1]

Receptor gastričnog inhibitornog polipeptida (GIP-R, glukozno zavisni insulinotropni polipeptidni receptor) je protein koji je kod ljudi kodiran GIPR genom.^[1]^[2] GIP-R je sedam transmembranski protein prisutan u beta ćelijama u pancreasu.^[3]^[4]

Funkcija

Gastrični inhibitorni polipeptid (GIP, glukozno zavisni insulinotropni polipeptid) je 42 aminokiseline dug polipeptid koji sintetišu K ćelije dvanaestopalačnog i tankih creva. On je originalno identifikovan kao sastojak stomačnog ekstrakta koji inhibira sekreciju želudačne kiseline i oslobađanje gastrina, ali je naknadno pokazano da potentno stimuliše otpuštanje insulina u prisustvu povišenih nivoa glukoze. Insulinotropno dejstvo na pankreasne beta ćelije je stoga njegova glavna fiziološka uloga. Zajedno sa glukagonu sličnim peptidom-1, GIP je u velikoj meri odgovoran za sekreciju insulina nakon jela. On učestvuje u nekoliko različitih oblika anaboličkog otpuštaja.^[1]

Reference

^ ^а ^б „Entrez Gene: gastric inhibitory polypeptide receptor”.
^ Stoffel M, Fernald AA, Le Beau MM, Bell GI (1995). „Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization”. Genomics. 28 (3): 607—609. PMID 7490109. doi:10.1006/geno.1995.1203.
^ „Gastrointestinal Hormones and Peptides”. Архивирано из оригинала 06. 12. 2007. г. Приступљено 24. 08. 2007.
^ Brubaker PL, Drucker DJ (2002). „Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors”. Recept. Channels. 8 (3–4): 179—188. PMID 12529935. doi:10.1080/10606820213687.

Literatura

Yamada Y, Seino Y (2005). „Physiology of GIP--a lesson from GIP receptor knockout mice”. Horm. Metab. Res. 36 (11–12): 771—774. PMID 15655707. doi:10.1055/s-2004-826162.
Gremlich S; Porret A; Hani EH; et al. (1995). „Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor”. Diabetes. 44 (10): 1202—1208. PMID 7556958. doi:10.2337/diabetes.44.10.1202.
Volz A; Göke R; Lankat-Buttgereit B; et al. (1995). „Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma”. FEBS Lett. 373 (1): 23—29. PMID 7589426. doi:10.1016/0014-5793(95)01006-Z.
Usdin TB; Mezey E; Button DC; et al. (1994). „Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain”. Endocrinology. 133 (6): 2861—2870. PMID 8243312. doi:10.1210/en.133.6.2861.
Yamada Y; Hayami T; Nakamura K; et al. (1996). „Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA”. Genomics. 29 (3): 773—776. PMID 8575774. doi:10.1006/geno.1995.9937.
Gallwitz B; Witt M; Morys-Wortmann C; et al. (1997). „GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1”. Regul. Pept. 63 (1): 17—22. PMID 8795084. doi:10.1016/0167-0115(96)00019-5.
N'Diaye N; Tremblay J; Hamet P; et al. (1998). „Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushing's syndrome”. J. Clin. Endocrinol. Metab. 83 (8): 2781—2785. PMID 9709947. doi:10.1210/jc.83.8.2781.
Tseng CC, Zhang XY (2000). „Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling”. Endocrinology. 141 (3): 947—952. PMID 10698169. doi:10.1210/en.141.3.947.
Bollag RJ; Zhong Q; Phillips P; et al. (2000). „Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors”. Endocrinology. 141 (3): 1228—1235. PMID 10698200. doi:10.1210/en.141.3.1228.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—16903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Baldacchino V; Oble S; Hamet P; et al. (2003). „Partial characterisation of the 5' flanking region of the human GIP receptor (GIPR) gene”. Endocr. Res. 28 (4): 577—577. PMID 12530665. doi:10.1081/ERC-120016843.
Antonini SR; N'Diaye N; Hamet P; et al. (2003). „Analysis of the putative promoter region of the GIP receptor gene (GIPR) in GIP-dependent Cushing's syndrome (CS)”. Endocr. Res. 28 (4): 755—756. PMID 12530694. doi:10.1081/ERC-120017003.
Manhart S; Hinke SA; McIntosh CH; et al. (2003). „Structure-function analysis of a series of novel GIP analogues containing different helical length linkers”. Biochemistry. 42 (10): 3081—3088. PMID 12627975. doi:10.1021/bi026868e.
Ding KH, Zhong Q, Isales CM (2003). „Glucose-dependent insulinotropic peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1”. Am. J. Physiol. Endocrinol. Metab. 285 (2): E390—6. PMID 12721154. doi:10.1152/ajpendo.00509.2002.
Grimwood J; Gordon LA; Olsen A; et al. (2004). „The DNA sequence and biology of human chromosome 19”. Nature. 428 (6982): 529—535. PMID 15057824. doi:10.1038/nature02399.
Hansotia T; Baggio LL; Delmeire D; et al. (2004). „Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors”. Diabetes. 53 (5): 1326—1335. PMID 15111503. doi:10.2337/diabetes.53.5.1326.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—2127. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Baldacchino V; Oble S; Hamet P; et al. (2005). „The Sp transcription factor family is involved in the cellular expression of the human GIP-R gene promoter”. Endocr. Res. 30 (4): 805—806. PMID 15666829. doi:10.1081/ERC-200044046.

Vidi još

Glukagonska receptorska familija

Spoljašnje veze

„Glucagon Receptor Family: GIP”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.
gastric+inhibitory+polypeptide+receptor на US National Library of Medicine Medical Subject Headings (MeSH)

[entrez-1] а ^б „Entrez Gene: gastric inhibitory polypeptide receptor”.

[pmid7490109-2] Stoffel M, Fernald AA, Le Beau MM, Bell GI (1995). „Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization”. Genomics. 28 (3): 607—609. PMID 7490109. doi:10.1006/geno.1995.1203.

[Helmenstine-3] „Gastrointestinal Hormones and Peptides”. Архивирано из оригинала 06. 12. 2007. г. Приступљено 24. 08. 2007.

[pmid12529935-4] Brubaker PL, Drucker DJ (2002). „Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors”. Recept. Channels. 8 (3–4): 179—188. PMID 12529935. doi:10.1080/10606820213687.

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