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Receptor lizofosfatidne kiseline 5
Receptor lizofosfatidne kiseline 5
Identifikatori
Simboli	LPAR5; GPR92 ; GPR93; KPG_010; LPA5
Vanjski ID	OMIM: 606926 MGI: 2685918 HomoloGene: 10696 IUPHAR: GeneCards: LPAR5 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu sličnog receptora; • receptorska aktivnost; • aktivnost purinergičkog nukleotidnog receptora, G-protein spregnutog;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• prenos signal; • signalni put G-protein spregnutog receptora; • biološki_proces;
Ortolozi
Vrsta	Čovek
Entrez	57121
Ensembl	ENSG00000184574
UniProt	Q9H1C0
RefSeq (mRNA)	NM_020400
RefSeq (protein)	NP_065133
Lokacija (UCSC)	Chr 12:; 6.6 - 6.62 Mb
PubMed pretraga	[1]

LPA₅, receptor lizofosfatidne kiseline 5, je protein koji je kod čoveka kodiran LPAR5 gena.^[1]^[2]^[3]^[4]^[5] LPA₅ je G protein-spregnuti receptor koji vezuje lipidni signalni molekul lizofosfatidnu kiselinu (LPA).^[6]

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Lizofosfolipidni receptor

Literatura

^ Adhr, Consortium; Strom, Tim M.; White, Kenneth E.; Evans, Wayne E.; O'Riordan, Jeffery L.H.; Speer, Marcy C.; Lorenz-Depiereux, Bettina; Grabowski, Monika; Meitinger, Thomas (2000). „Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23”. Nat Genet. 26 (3): 345—8. PMID 11062477. doi:10.1038/81664.
^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (2001). „Discovery and mapping of ten novel G protein-coupled receptor genes”. Gene. 275 (1): 83—91. PMID 11574155. doi:10.1016/S0378-1119(01)00651-5.
^ Lee CW, Rivera R, Gardell S, Dubin AE, Chun J (2006). „GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5”. J Biol Chem. 281 (33): 23589—97. PMID 16774927. doi:10.1074/jbc.M603670200.
^ Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, Owman C, Sillard R, Leeb-Lundberg LM, Olde B (2006). „Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes”. J Pharmacol Exp Ther. 318 (2): 619—28. PMID 16651401. doi:10.1124/jpet.105.098848.
^ „Entrez Gene: GPR92 G protein-coupled receptor 92”.
^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (2010). „LPA Receptors: Subtypes and Biological Actions”. Annual Review of Pharmacology and Toxicology. 50 (1): 157—186. PMID 20055701. doi:10.1146/annurev.pharmtox.010909.105753.