Ovaj protein je član familije G protein spregnutih receptora. On je jedan od četiri receptora identifikovana za prostaglandin E2 (PGE2). Gq proteini posreduju aktivnost ovog receptora putem sistema fosfatidilinozitol-kalcijum sekundarnog glasnika. Ispitivanja na nokaut miševima sugeriraju da ovaj receptor posreduje algeziju, i učestvuje u regulaciji krvnog pritiska. Studije na miševima takođe pokazuju da ovaj gen posreduje adrenokortikotropni hormonski respons na bakterijski endotoksin.[1]
Coleman RA, Smith WL, Narumiya S (1994). „International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.”. Pharmacol. Rev. 46 (2): 205—29. PMID7938166.
Lee TY, Watanabe Y (1975). „A nonlinear regression model as applied to the comparison of axis-angles of electrocardiographic systems.”. Japanese heart journal. 16 (3): 243—56. PMID1160156.
Duncan AM; Anderson LL; Funk CD; et al. (1995). „Chromosomal localization of the human prostanoid receptor gene family.”. Genomics. 25 (3): 740—2. PMID7759114. doi:10.1016/0888-7543(95)80022-E.CS1 одржавање: Експлицитна употреба et al. (веза)
Funk CD; Furci L; FitzGerald GA; et al. (1994). „Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.”. J. Biol. Chem. 268 (35): 26767—72. PMID8253813.CS1 одржавање: Експлицитна употреба et al. (веза)
Kyveris A, Maruscak E, Senchyna M (2002). „Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR.”. Mol. Vis. 8: 51—8. PMID11951086.
Richards JA, Brueggemeier RW (2003). „Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes.”. J. Clin. Endocrinol. Metab. 88 (6): 2810—6. PMID12788892. doi:10.1210/jc.2002-021475.
Kitamura T; Itoh M; Noda T; et al. (2004). „Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice.”. Cancer Sci. 94 (7): 618—21. PMID12841871. doi:10.1111/j.1349-7006.2003.tb01492.x.CS1 одржавање: Експлицитна употреба et al. (веза)
Moreland RB; Kim N; Nehra A; et al. (2004). „Functional prostaglandin E (EP) receptors in human penile corpus cavernosum.”. Int. J. Impot. Res. 15 (5): 362—8. PMID14562138. doi:10.1038/sj.ijir.3901042.CS1 одржавање: Експлицитна употреба et al. (веза)
Su JL; Shih JY; Yen ML; et al. (2004). „Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma.”. Cancer Res. 64 (2): 554—64. PMID14744769. doi:10.1158/0008-5472.CAN-03-1301.CS1 одржавање: Експлицитна употреба et al. (веза)
Han C, Wu T (2005). „Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.”. J. Biol. Chem. 280 (25): 24053—63. PMID15855163. doi:10.1074/jbc.M500562200.
Nicola C; Timoshenko AV; Dixon SJ; et al. (2005). „EP1 receptor-mediated migration of the first trimester human extravillous trophoblast: the role of intracellular calcium and calpain.”. J. Clin. Endocrinol. Metab. 90 (8): 4736—46. PMID15886234. doi:10.1210/jc.2005-0413.CS1 одржавање: Експлицитна употреба et al. (веза)
Han C, Michalopoulos GK, Wu T (2006). „Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells.”. J. Cell. Physiol. 207 (1): 261—70. PMID16331686. doi:10.1002/jcp.20560.
„Prostanoid Receptors: EP1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.
