Ovaj protein je član latrofilinske familije G protein spregnutih receptora (GPCR). Latrofilini mogu da učestvuju u ćelijskoj adheziji i u prenosu signala. Endogeno proteolitičko razlaganje unutar cisteinom bogatog GPS (GPCR proteolizno mesto) domena proizvodi dve podjedinice (veliku ekstracelularnu N-terminalnu adhezionu jedinicu i podjedinicu koja je u znatno meri slična sa sekretinskom/kalcitoninskom familijom). Ovi domeni su nekovalentno vezani na ćelijskoj membrani. Latrofilin-1 vezuje neurotoksin iz venuma pauka crna udovica, alfa-latrotoksin.[2]
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