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Angiotenzinski II receptor, tip 1
Angiotenzinski II receptor, tip 1
Identifikatori
Simboli	AGTR1; AG2S; AGTR1A; AGTR1B; AT1; AT1B; AT2R1; AT2R1A; AT2R1B; HAT1R
Vanjski ID	OMIM: 106165 MGI: 87964 HomoloGene: 3556 IUPHAR: AT1 GeneCards: AGTR1 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost; • aktivnost angiotenzin tip II receptora; • aktivnost bradikininskog receptora; • aktivnost C-X-C hemokinskog receptora;
Celularna komponenta	• ćelijska membrana; • integralno sa ćelijskom membranom; • membrana; • integralno sa membranom;
Biološki proces	• prenos signala; • signalni put G-protein spregnutog receptora; • G-protein signalizacija, spregnuta sa IP3 sekundarnim glasnikom (aktivacija fosfolipaze C); • elevacija koncentracije citosolnih jona kalcijuma; • sekrecija fluida; • cirkulacija;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	185
Ensembl	ENSG00000144891
UniProt	P30556
RefSeq (mRNA)	NM_000685
RefSeq (protein)	NP_000676
Lokacija (UCSC)	Chr 3:; 149.9 - 149.94 Mb
PubMed pretraga	[1]

AGTR1 (Angiotenzinski II receptor, tip 1, AT₁ receptor) je angiotenzinski receptor. On ima simpatomimetičko dejstvo i reguliše sekreciju aldosterona. On je značajan efektor kontrole krvnog pritiska i zapremine u kardiovaskularnom sistemu. Antagonisti angiotenzin II receptora su lekovi za hipertenziju, dijabetesnu nefropatiju i srčanu insuficijenciju. AGTR1 je najbolje istraženi angiotenzinski receptor.

Mehanizam

Angiotenzinski receptori se aktiviraju vazokonstriktivnim peptidom angiotenzin II. Aktivirani receptor se spreže sa G_q/11, aktivira fosfolipazu C i povišava koncentraciju citosolnog Ca²⁺, čime se zatim inicira ćelijski respons kao što je stimulacija proteinske kinaze C. Aktivirani receptor takođe inhibira adenilat ciklazu i razne tirozinske kinaze.^[1]

Literatura

^ Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S (2007). „Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology”. Clin. Sci. 112 (8): 417—28. PMID 17346243. doi:10.1042/CS20060342.

Dodatna literatura

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Spoljašnje veze

„Angiotensin Receptors: AT₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 28. 02. 2014. г.