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G protein-spregnuti receptor 120
G protein-spregnuti receptor 120
Identifikatori
Simboli	GPR120; GPR129; GT01; MGC119984; PGR4
Vanjski ID	OMIM: 609044 MGI: 2147577 HomoloGene: 18769 IUPHAR: GPR120 GeneCards: GPR120 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu sličnog receptora; • receptorska aktivnost; • masno kiselinsko vezivanje;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana; • vezikule endocitoze;
Biološki proces	• prenos signal; • signalni put G-protein spregnutog receptora; • hormonska sekrecija;
Ortolozi
Vrsta	Čovek
Entrez	338557
Ensembl	ENSG00000186188
UniProt	Q5NUL3
RefSeq (mRNA)	NM_181745
RefSeq (protein)	NP_859529
Lokacija (UCSC)	Chr 10:; 95.32 - 95.34 Mb
PubMed pretraga	[1]

GPR120, G protein-spregnuti receptor 120, je protein koji je kod čoveka kodiran GPR120 genom.^[1]^[2] i Za GPR120 je bilo pokazano da posreduje antiinflamatorne i insulin-senzibilizujuće efekte omega 3 masnih kiselina.^[3]

Literatura

^ Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB (2003). „Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives”. FEBS Lett. 554 (3): 381—8. PMID 14623098. doi:10.1016/S0014-5793(03)01196-7.
^ „Entrez Gene: GPR120 G protein-coupled receptor 120”.
^ Oh DY; Talukdar S; Bae EJ; et al. (2010). „GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects”. Cell. 142 (5): 687—98. PMID 20813258. doi:10.1016/j.cell.2010.07.041. Приступљено 09. 04. 2011.

Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Vassilatis DK; Hohmann JG; Zeng H; et al. (2003). „The G protein-coupled receptor repertoires of human and mouse.”. Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903—8. PMC 153653 . PMID 12679517. doi:10.1073/pnas.0230374100.
Deloukas P; Earthrowl ME; Grafham DV; et al. (2004). „The DNA sequence and comparative analysis of human chromosome 10.”. Nature. 429 (6990): 375—81. PMID 15164054. doi:10.1038/nature02462.
Hirasawa A; Tsumaya K; Awaji T; et al. (2005). „Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.”. Nat. Med. 11 (1): 90—4. PMID 15619630. doi:10.1038/nm1168.
Oh JH; Yang JO; Hahn Y; et al. (2006). „Transcriptome analysis of human gastric cancer.”. Mamm. Genome. 16 (12): 942—54. PMID 16341674. doi:10.1007/s00335-005-0075-2.