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Receptor ukusa tip 2 član 50
Receptor ukusa tip 2 član 50
Identifikatori
Simboli	TAS2R50; T2R50; T2R51; TAS2R51
Vanjski ID	OMIM: 609627 HomoloGene: 88474 IUPHAR: GeneCards: TAS2R50 Gene
Ontologija gena
Molekularna funkcija	• aktivnost receptora ukusa;
Celularna komponenta	• integralno sa membranom;
Biološki proces	• signalni put G-protein spregnutog receptora;
Ortolozi
Vrsta	Čovek
Entrez	259296
Ensembl	ENSG00000212126
UniProt	P59544
RefSeq (mRNA)	NM_176890.2
RefSeq (protein)	NP_795371.2
Lokacija (UCSC)	Chr 12:; 11.14 - 11.14 Mb
PubMed pretraga	[1]

Receptor ukusa tip 2 član 50 je protein koji je kod ljudi kodiran TAS2R50 genom.^[1]^[2]^[3]^[4]

TAS2R50 pripada velikoj familiji TAS2R receptora. TAS2R receptori su izraženi na površini ćelija ukusa i posreduju percepciju gorkog ukusa putem G protein spregnutog puta sekundarnih glasnika (Conte et al., 2002).^[4]

Reference

^ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002). „The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides”. Nat Genet. 32 (3): 397—401. PMID 12379855. doi:10.1038/ng1014.
^ Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ (2003). „Identification and characterization of human taste receptor genes belonging to the TAS2R family”. Cytogenet Genome Res. 98 (1): 45—53. PMID 12584440. doi:10.1159/000068546.
^ Shiffman D, Ellis SG, Rowland CM, Malloy MJ, Luke MM, Iakoubova OA, Pullinger CR, Cassano J, Aouizerat BE, Fenwick RG, Reitz RE, Catanese JJ, Leong DU, Zellner C, Sninsky JJ, Topol EJ, Devlin JJ, Kane JP (2005). „Identification of Four Gene Variants Associated with Myocardial Infarction”. Am J Hum Genet. 77 (4): 596—605. PMC 1275608 . PMID 16175505. doi:10.1086/491674.
^ ^а ^б „Entrez Gene: TAS2R50 taste receptor, type 2, member 50”.

Literatura

Margolskee RF (2002). „Molecular mechanisms of bitter and sweet taste transduction”. J. Biol. Chem. 277 (1): 1—4. PMID 11696554. doi:10.1074/jbc.R100054200.
Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste”. Curr. Opin. Neurobiol. 12 (4): 366—71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Zhang Y; Hoon MA; Chandrashekar J; et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways”. Cell. 112 (3): 293—301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes”. Mol. Biol. Evol. 22 (3): 432—6. PMID 15496549. doi:10.1093/molbev/msi027.
Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates”. Genetics. 170 (1): 313—26. PMC 1449719 . PMID 15744053. doi:10.1534/genetics.104.037523.

Vidi još

Receptor ukusa

[pmid12379855-1] Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002). „The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides”. Nat Genet. 32 (3): 397—401. PMID 12379855. doi:10.1038/ng1014.

[pmid12584440-2] Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ (2003). „Identification and characterization of human taste receptor genes belonging to the TAS2R family”. Cytogenet Genome Res. 98 (1): 45—53. PMID 12584440. doi:10.1159/000068546.

[pmid16175505-3] Shiffman D, Ellis SG, Rowland CM, Malloy MJ, Luke MM, Iakoubova OA, Pullinger CR, Cassano J, Aouizerat BE, Fenwick RG, Reitz RE, Catanese JJ, Leong DU, Zellner C, Sninsky JJ, Topol EJ, Devlin JJ, Kane JP (2005). „Identification of Four Gene Variants Associated with Myocardial Infarction”. Am J Hum Genet. 77 (4): 596—605. PMC 1275608 . PMID 16175505. doi:10.1086/491674.

[entrez-4] а ^б „Entrez Gene: TAS2R50 taste receptor, type 2, member 50”.

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