Neurotrofni moždani faktor

Neurotrofni moždani faktor
PDB prikaz baziran na 1bnd[1].
Dostupne strukture
1B8M​, 1BND​
Identifikatori
Simboli BDNF; ANON2; BULN2
Vanjski ID OMIM: 113505 MGI: 88145 HomoloGene: 7245 GeneCards: BDNF Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 627 12064
Ensembl ENSG00000176697 ENSMUSG00000048482
UniProt P23560 P21237
RefSeq (mRNA) NM_001143805.1 NM_001048139.1
RefSeq (protein) NP_001137277.1 NP_001041604.1
Lokacija (UCSC) Chr 11:
27.68 - 27.74 Mb		 Chr 2:
109.67 - 109.73 Mb
PubMed pretraga [1] [2]

Neurotrofni moždani faktor (BDNF) je sekretorni protein[2] koji je kod ljudi kodiran BDNF genom.[3][4] BDNF je član neurotrofinske familije faktora rasta, koja je srodna sa kanoničkim „nervnim faktorima rasta“, NGF. Neurotrofinski faktori su prisutni u mozgu i u perifernom nervnom sistemu.

Reference

  1. ^ Robinson, R. C.; Radziejewski, C.; Stuart, D. I.; Jones, E. Y. (1995). „Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer”. Biochemistry. 34 (13): 4139—4146. PMID 7703225. doi:10.1021/bi00013a001. 
  2. ^ Binder DK, Scharfman HE (2004). „Brain-derived Neurotrophic Factor”. Growth Factors. 22 (3): 123—31. PMC 2504526 Слободан приступ. PMID 15518235. doi:10.1080/08977190410001723308. 
  3. ^ Jones KR, Reichardt LF (1990). „Molecular cloning of a human gene that is a member of the nerve growth factor family”. Proc. Natl. Acad. Sci. U.S.A. 87 (20): 8060—4. Bibcode:1990PNAS...87.8060J. PMC 54892 Слободан приступ. PMID 2236018. doi:10.1073/pnas.87.20.8060. 
  4. ^ Maisonpierre PC, Le Beau MM, Espinosa R, Ip NY, Belluscio L, de la Monte SM, Squinto S, Furth ME, Yancopoulos GD (1991). „Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations”. Genomics. 10 (3): 558—68. PMID 1889806. 

Spoljašnje veze