PROFILPELAJAR.COM

Venlafaksin
Klinički podaci
Prodajno ime	Effexor, Effexor XR, Elafax
Drugs.com	Monografija
Način primene	Oralno
Farmakokinetički podaci
Poluvreme eliminacije	5 h
Identifikatori
CAS broj	93413-69-5
ATC kod	N06AX16 (WHO), N06AX23
PubChem	CID 5656
DrugBank	DB00285
ChemSpider	5454
KEGG	C07187
ChEBI	CHEBI:9943
ChEMBL	CHEMBL637
Hemijski podaci
Formula	C17H27NO2
Molarna masa	277,402
	SMILES COC1=CC=C(C=C1)C(CN(C)C)C1(O)CCCCC1; ;
	InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3 ; Key:PNVNVHUZROJLTJ-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	215—217 °C (419—423 °F)

Venlafaksin je organsko jedinjenje, koje sadrži 17 atoma ugljenika i ima molekulsku masu od 277,402 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	3
Broj donora vodonika	1
Broj rotacionih veza	5
Particioni koeficijent^[8] (ALogP)	3,0
Rastvorljivost^[9] (logS, log(mol/L))	−3,9
Polarna površina^[10] (PSA, Å²)	32,7

Reference

^ Golden, R. N.; Nicholas, L. (2000). „Antidepressant efficacy of venlafaxine”. Depress Anxiety. 12 (1): 45—9. PMID 11098413. doi:10.1002/1520-6394(2000)12:1+<45::AID-DA5>3.0.CO;2-5.
^ Thase, M. E.; Clayton, A. H.; Haight, B. R.; Thompson, A. H.; Modell, J. G.; Johnston, J. A. (октобар 2006). „A double-blind comparison between bupropion XL and venlafaxine XR: Sexual functioning, antidepressant efficacy, and tolerability”. J Clin Psychopharmacol. 26 (5): 482—8. PMID 16974189. doi:10.1097/01.jcp.0000239790.83707.ab.
^ Bielski, R. J.; Ventura, D.; Chang, C. C. (септембар 2004). „A double-blind comparison of escitalopram and venlafaxine extended release in the treatment of major depressive disorder”. Journal of Clinical Psychiatry. 65 (9): 1190—6. PMID 15367045. doi:10.4088/jcp.v65n0906.
^ Rowbotham, M. C.; Goli, V.; Kunz, N. R.; Lei, D. (август 2004). „Venlafaxine extended release in the treatment of painful diabetic neuropathy: A double-blind, placebo-controlled study”. Pain. 110 (3): 697—706. PMID 15288411. doi:10.1016/j.pain.2004.05.010.
^ Ozyalcin, S. N.; Talu, G. K.; Kiziltan, E.; Yucel, B.; Ertas, M.; Disci, R. (фебруар 2005). „The efficacy and safety of venlafaxine in the prophylaxis of migraine”. Headache. 45 (2): 144—52. PMID 15705120. doi:10.1111/j.1526-4610.2005.05029.x.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. doi:10.1021/jp980230o.
^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Venlafaxine

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Golden, R. N.; Nicholas, L. (2000). „Antidepressant efficacy of venlafaxine”. Depress Anxiety. 12 (1): 45—9. PMID 11098413. doi:10.1002/1520-6394(2000)12:1+<45::AID-DA5>3.0.CO;2-5.

[2] Thase, M. E.; Clayton, A. H.; Haight, B. R.; Thompson, A. H.; Modell, J. G.; Johnston, J. A. (октобар 2006). „A double-blind comparison between bupropion XL and venlafaxine XR: Sexual functioning, antidepressant efficacy, and tolerability”. J Clin Psychopharmacol. 26 (5): 482—8. PMID 16974189. doi:10.1097/01.jcp.0000239790.83707.ab.

[3] Bielski, R. J.; Ventura, D.; Chang, C. C. (септембар 2004). „A double-blind comparison of escitalopram and venlafaxine extended release in the treatment of major depressive disorder”. Journal of Clinical Psychiatry. 65 (9): 1190—6. PMID 15367045. doi:10.4088/jcp.v65n0906.

[4] Rowbotham, M. C.; Goli, V.; Kunz, N. R.; Lei, D. (август 2004). „Venlafaxine extended release in the treatment of painful diabetic neuropathy: A double-blind, placebo-controlled study”. Pain. 110 (3): 697—706. PMID 15288411. doi:10.1016/j.pain.2004.05.010.

[5] Ozyalcin, S. N.; Talu, G. K.; Kiziltan, E.; Yucel, B.; Ertas, M.; Disci, R. (фебруар 2005). „The efficacy and safety of venlafaxine in the prophylaxis of migraine”. Headache. 45 (2): 144—52. PMID 15705120. doi:10.1111/j.1526-4610.2005.05029.x.

[6] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[7] Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[8] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. doi:10.1021/jp980230o.

[9] Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[10] Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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