SKF-97541

SKF-97541
(IUPAC) ime
3-aminopropil(metil)fosforasta kiselina
Klinički podaci
Identifikatori
CAS broj 127729-35-5
ATC kod nije dodeljen
PubChem[1][2] 5230
Hemijski podaci
Formula C4H12NO2P 
Mol. masa 137,117 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

SKF-97,541 je jedinjenje koje se koristi u naučnim istraživanjima, i koje je prvenstveno selektivni agonist GABAB receptora.[3] On ima sedativno ispoljava sedativno dejstvo u životinjskim studijama, i u širokoj je upotrebi u istraživanju potencijalnog tretmana za raznih tipove narkomanije.[4][5][6][7][8][9]

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Seabrook GR, Howson W, Lacey MG (December 1990). „Electrophysiological characterization of potent agonists and antagonists at pre- and postsynaptic GABAB receptors on neurones in rat brain slices”. British Journal of Pharmacology 101 (4): 949–57. PMC 1917862. PMID 1964824. 
  4. ↑ Jackson GL, Kuehl D (May 2002). „The GABA(B) antagonist CGP 52432 attenuates the stimulatory effect of the GABA(B) agonist SKF 97541 on luteinizing hormone secretion in the male sheep”. Experimental Biology and Medicine (Maywood, N.J.) 227 (5): 315–20. PMID 11976401. 
  5. ↑ Besheer J, Lepoutre V, Hodge CW (July 2004). „GABA(B) receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice”. Psychopharmacology 174 (3): 358–66. DOI:10.1007/s00213-003-1769-3. PMID 14985930. 
  6. ↑ Carter LP, Chen W, Coop A, Koek W, France CP (May 2006). „Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348”. European Journal of Pharmacology 538 (1-3): 85–93. DOI:10.1016/j.ejphar.2006.03.039. PMID 16647701. 
  7. ↑ Koek W, Mercer SL, Coop A (June 2007). „Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348”. Psychopharmacology 192 (3): 407–14. DOI:10.1007/s00213-007-0718-y. PMID 17277933. 
  8. ↑ Koek W, Mercer SL, Coop A, France CP (September 2009). „Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348)”. The Journal of Pharmacology and Experimental Therapeutics 330 (3): 876–83. DOI:10.1124/jpet.109.151845. PMID 19564487. 
  9. ↑ Frankowska M, Nowak E, Filip M (2009). „Effects of GABAB receptor agonists on cocaine hyperlocomotor and sensitizing effects in rats”. Pharmacological Reports : PR 61 (6): 1042–9. PMID 20081239. 

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