1ZXQ
3384
15896
ENSG00000108622
ENSMUSG00000001029
P13598
P35330
NM_001099789NM_000873NM_001099786NM_001099787NM_001099788
NM_010494
NP_000864NP_001093256NP_001093257NP_001093258NP_001093259
NP_034624
Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human gene, and the protein resulting from it.
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2–9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein.
ICAM-2 molecules regulate spermatid adhesion on Sertoli cell on the apical side of the blood-testis barrier (towards the lumen), thus playing a major role in spermatogenesis.[5]
This protein may also play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.[6]
ICAM2 has been shown to interact with EZR.[7] It has also been shown to bind to P9 (Uniprot: B2UM07), a secreted protein from Akkermansia muciniphila.[8]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This membrane protein–related article is a stub. You can help Wikipedia by expanding it.
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