3P2T
11006
14727
n/a
ENSMUSG00000112023
Q8NHJ6
Q61450
NM_001278430NM_006847NM_001394933NM_001394934NM_001394935NM_001394936NM_001394937NM_001394938NM_001394939
NM_001291892NM_001291893NM_008147
NP_001265355NP_001265356NP_001265357NP_001265358NP_001265359
NP_001278821NP_001278822NP_032173
Leukocyte immunoglobulin-like receptor subfamily B member 4 is a protein that in humans is encoded by the LILRB4 gene.[5][6][7]
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on monocytic cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. LILRB4 has also been proposed to be a potential target for tumor immunotherapy. It has been shown to express on tumor-associated macrophages and negatively regulate immune response in tumor.[8] The expression of LILRB4 on monocytic myeloid leukemia cells supports infiltration and inhibits T cell proliferation. Multiple transcript variants encoding different isoforms have been found for this gene.[7]
LILRB4 has been shown to interact with PTPN6[9] and INPP5D (SHIP-1).[10]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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