KLRD1

KLRD1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKLRD1, CD94, killer cell lectin like receptor D1
External IDsOMIM: 602894; MGI: 1196275; HomoloGene: 1705; GeneCards: KLRD1; OMA:KLRD1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

3824

16643

Ensembl

ENSG00000134539

ENSMUSG00000030165

UniProt

Q13241

O54707

RefSeq (mRNA)

NM_010654

RefSeq (protein)

NP_034784

Location (UCSC)Chr 12: 10.23 – 10.33 MbChr 6: 129.57 – 129.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD94 (Cluster of Differentiation 94), also known as killer cell lectin-like receptor subfamily D, member 1 (KLRD1) is a human gene.[5]

The protein encoded by CD94 gene is a lectin, cluster of differentiation and a receptor that is involved in cell signaling and is expressed on the surface of natural killer cells in the innate immune system. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.

Function

Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. KLRD1 has two alternatively spliced variants that differ in the presence or absence of exon 2 sequence.[5]

Interactions

KLRD1 has been shown to interact with KLRC2.[6][7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134539 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030165 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: KLRD1 killer cell lectin-like receptor subfamily D, member 1".
  6. ^ Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH (Dec 1996). "Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits". Journal of Immunology. 157 (11): 4741–5. doi:10.4049/jimmunol.157.11.4741. PMID 8943374.
  7. ^ Ding Y, Sumitran S, Holgersson J (May 1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells". Scandinavian Journal of Immunology. 49 (5): 459–65. doi:10.1046/j.1365-3083.1999.00566.x. PMID 10320637. S2CID 28500838.

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