CEACAM5

CEACAM5
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1E07, 2QSQ, 2QST, 2VER
Identifiers
Aliases	CEACAM5, CD66e, CEA, carcinoembryonic antigen related cell adhesion molecule 5, CEA cell adhesion molecule 5
External IDs	OMIM: 114890; HomoloGene: 128801; GeneCards: CEACAM5; OMA:CEACAM5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	41,730,433 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; mucosa of sigmoid colon; ; nasal epithelium; ; rectum; ; mucosa of transverse colon; ; mucosa of pharynx; ; appendix; ; oral cavity; ; palpebral conjunctiva; ; trachea;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	GPI anchor binding; protein homodimerization activity; identical protein binding;
Cellular component	anchored component of membrane; basolateral plasma membrane; integral component of plasma membrane; extracellular exosome; membrane; integral component of external side of plasma membrane; extracellular region; plasma membrane; cell surface; apical plasma membrane;
Biological process	homotypic cell-cell adhesion; negative regulation of apoptotic process; negative regulation of anoikis; negative regulation of myotube differentiation; C-terminal protein lipidation; leukocyte migration; apoptotic process; cell adhesion; homophilic cell adhesion via plasma membrane adhesion molecules; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;
	Sources:Amigo / QuickGO
Orthologs
	1048
	n/a
	ENSG00000105388
	n/a
	P06731
	n/a
	NM_001291484; NM_001308398; NM_004363
	n/a
	NP_001278413; NP_001295327; NP_004354
	n/a
	Wikidata
View/Edit Human

Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a member of the carcinoembryonic antigen (CEA) gene family.^[3]

Functions

In the literature, CEACAM5 is often used as a synonym for cancer embryonic antigen (CEA), a well-known biomarker of many types of malignancies, such as colorectal cancer and non-small-cell lung cancer.^[4]^[5] Its primary function in the embryonic intestine and colon tumors is adhesion between epithelial cells.^[6] Also, it plays a significant role in the inhibition of differentiation ^[7] and apoptosis ^[8] in colon cells. There are evidences that high CEACAM5 expression is firmly associated with the CD133-positive colorectal cancer stem cells.^[9] High CEACAM5 expression has also been identified in ~25% of patients with advanced non-squamous (NSq) non-small cell lung cancer (NSCLC) detectable via IHC (immunohistochemistry).^[10]^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105388 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5".
^ Beauchemin N, Arabzadeh A (December 2013). "Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis". Cancer and Metastasis Reviews. 32 (3–4): 643–671. doi:10.1007/s10555-013-9444-6. PMID 23903773. S2CID 10344352.
^ Zhang X, Han X, Zuo P, Zhang X, Xu H (September 2020). "CEACAM5 stimulates the progression of non-small-cell lung cancer by promoting cell proliferation and migration". The Journal of International Medical Research. 48 (9): 300060520959478. doi:10.1177/0300060520959478. PMC 7536504. PMID 32993395.
^ Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP (April 1989). "Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule". Cell. 57 (2): 327–334. doi:10.1016/0092-8674(89)90970-7. PMID 2702691. S2CID 30740594.
^ Ilantzis C, DeMarte L, Screaton RA, Stanners CP (2002). "Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation". Neoplasia. 4 (2): 151–163. doi:10.1038/sj.neo.7900201. PMC 1550325. PMID 11896570.
^ Ordoñez C, Screaton RA, Ilantzis C, Stanners CP (July 2000). "Human carcinoembryonic antigen functions as a general inhibitor of anoikis". Cancer Research. 60 (13): 3419–3424. PMID 10910050.
^ Gisina A, Novikova S, Kim Y, Sidorov D, Bykasov S, Volchenko N, et al. (2021-01-01). "CEACAM5 overexpression is a reliable characteristic of CD133-positive colorectal cancer stem cells". Cancer Biomarkers. 32 (1): 85–98. doi:10.3233/CBM-203187. PMID 34092615. S2CID 235359543.
^ LaPointe N, Hertle N, Hsu SC, Kellis J, King N, Littrell J, et al. (2021-05-20). "Validation of an immunohistochemical assay, CEACAM5 IHC 769, under development for use with the antibody-drug conjugate tusamitamab ravtansine (SAR408701)". Journal of Clinical Oncology. 39 (15_suppl): e21030. doi:10.1200/JCO.2021.39.15_suppl.e21030. ISSN 0732-183X. S2CID 236398737.
^ Kim YJ, Li W, Zhelev DV, Mellors JW, Dimitrov DS, Baek DS (2023-02-27). "Chimeric antigen receptor-T cells are effective against CEACAM5 expressing non-small cell lung cancer cells resistant to antibody-drug conjugates". Frontiers in Oncology. 13: 1124039. doi:10.3389/fonc.2023.1124039. PMC 10010383. PMID 36923424.

Willcocks TC, Craig IW (November 1990). "Characterization of the genomic organization of human carcinoembryonic antigen (CEA): comparison with other family members and sequence analysis of 5' controlling region". Genomics. 8 (3): 492–500. doi:10.1016/0888-7543(90)90036-T. PMID 2286372.
Barnett T, Zimmermann W (1990). "Workshop report: proposed nomenclature for the carcinoembryonic antigen (CEA) gene family". Tumour Biology. 11 (1–2): 59–63. doi:10.1159/000217643. PMID 2309067.
Schrewe H, Thompson J, Bona M, Hefta LJ, Maruya A, Hassauer M, et al. (June 1990). "Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression". Molecular and Cellular Biology. 10 (6): 2738–2748. doi:10.1128/MCB.10.6.2738. PMC 360634. PMID 2342461.
Kamarck ME, Elting JJ, Hart JT, Goebel SJ, Rae PM, Nothdurft MA, et al. (August 1987). "Carcinoembryonic antigen family: expression in a mouse L-cell transfectant and characterization of a partial cDNA in bacteriophage lambda gt11". Proceedings of the National Academy of Sciences of the United States of America. 84 (15): 5350–5354. Bibcode:1987PNAS...84.5350K. doi:10.1073/pnas.84.15.5350. PMC 298853. PMID 2955415.
Zimmermann W, Ortlieb B, Friedrich R, von Kleist S (May 1987). "Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure". Proceedings of the National Academy of Sciences of the United States of America. 84 (9): 2960–2964. Bibcode:1987PNAS...84.2960Z. doi:10.1073/pnas.84.9.2960. PMC 304780. PMID 3033671.
Barnett T, Goebel SJ, Nothdurft MA, Elting JJ (July 1988). "Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains". Genomics. 3 (1): 59–66. doi:10.1016/0888-7543(88)90160-7. PMID 3220478.
Zimmermann W, Weber B, Ortlieb B, Rudert F, Schempp W, Fiebig HH, et al. (May 1988). "Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors". Cancer Research. 48 (9): 2550–2554. PMID 3356015.
Beauchemin N, Benchimol S, Cournoyer D, Fuks A, Stanners CP (September 1987). "Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen". Molecular and Cellular Biology. 7 (9): 3221–3230. doi:10.1128/MCB.7.9.3221. PMC 367958. PMID 3670312.
Oikawa S, Nakazato H, Kosaki G (January 1987). "Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence". Biochemical and Biophysical Research Communications. 142 (2): 511–518. doi:10.1016/0006-291X(87)90304-4. PMID 3814146.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hart SP, Ross JA, Ross K, Haslett C, Dransfield I (May 2000). "Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes". Cell Death and Differentiation. 7 (5): 493–503. doi:10.1038/sj.cdd.4400680. PMID 10800083.
Guignot J, Peiffer I, Bernet-Camard MF, Lublin DM, Carnoy C, Moseley SL, Servin AL (June 2000). "Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco-2/TC7 cells". Infection and Immunity. 68 (6): 3554–3563. doi:10.1128/IAI.68.6.3554-3563.2000. PMC 97642. PMID 10816511.
Boehm MK, Perkins SJ (June 2000). "Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23". FEBS Letters. 475 (1): 11–16. doi:10.1016/S0014-5793(00)01612-4. PMID 10854848. S2CID 5765612.
Screaton RA, DeMarte L, Dráber P, Stanners CP (August 2000). "The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor". The Journal of Cell Biology. 150 (3): 613–626. doi:10.1083/jcb.150.3.613. PMC 2175204. PMID 10931872.
Bajenova OV, Zimmer R, Stolper E, Salisbury-Rowswell J, Nanji A, Thomas P (August 2001). "Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells". The Journal of Biological Chemistry. 276 (33): 31067–31073. doi:10.1074/jbc.M104093200. PMID 11406629.
Wirth T, Soeth E, Czubayko F, Juhl H (2002). "Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth". Clinical & Experimental Metastasis. 19 (2): 155–160. doi:10.1023/A:1014566127493. PMID 11964079. S2CID 3138022.
Louhimo J, Carpelan-Holmström M, Alfthan H, Stenman UH, Järvinen HJ, Haglund C (October 2002). "Serum HCG beta, CA 72-4 and CEA are independent prognostic factors in colorectal cancer". International Journal of Cancer. 101 (6): 545–548. doi:10.1002/ijc.90009. PMID 12237895. S2CID 7030523.
Hampton R, Walker M, Marshall J, Juhl H (November 2002). "Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells". Oncogene. 21 (51): 7817–7823. doi:10.1038/sj.onc.1205906. PMID 12420218.

External links

CEACAM5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CEACAM5 genome location and CEACAM5 gene details page in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105388 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5".

[4] Beauchemin N, Arabzadeh A (December 2013). "Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis". Cancer and Metastasis Reviews. 32 (3–4): 643–671. doi:10.1007/s10555-013-9444-6. PMID 23903773. S2CID 10344352.

[5] Zhang X, Han X, Zuo P, Zhang X, Xu H (September 2020). "CEACAM5 stimulates the progression of non-small-cell lung cancer by promoting cell proliferation and migration". The Journal of International Medical Research. 48 (9): 300060520959478. doi:10.1177/0300060520959478. PMC 7536504. PMID 32993395.

[6] Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP (April 1989). "Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule". Cell. 57 (2): 327–334. doi:10.1016/0092-8674(89)90970-7. PMID 2702691. S2CID 30740594.

[7] Ilantzis C, DeMarte L, Screaton RA, Stanners CP (2002). "Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation". Neoplasia. 4 (2): 151–163. doi:10.1038/sj.neo.7900201. PMC 1550325. PMID 11896570.

[8] Ordoñez C, Screaton RA, Ilantzis C, Stanners CP (July 2000). "Human carcinoembryonic antigen functions as a general inhibitor of anoikis". Cancer Research. 60 (13): 3419–3424. PMID 10910050.

[9] Gisina A, Novikova S, Kim Y, Sidorov D, Bykasov S, Volchenko N, et al. (2021-01-01). "CEACAM5 overexpression is a reliable characteristic of CD133-positive colorectal cancer stem cells". Cancer Biomarkers. 32 (1): 85–98. doi:10.3233/CBM-203187. PMID 34092615. S2CID 235359543.

[10] LaPointe N, Hertle N, Hsu SC, Kellis J, King N, Littrell J, et al. (2021-05-20). "Validation of an immunohistochemical assay, CEACAM5 IHC 769, under development for use with the antibody-drug conjugate tusamitamab ravtansine (SAR408701)". Journal of Clinical Oncology. 39 (15_suppl): e21030. doi:10.1200/JCO.2021.39.15_suppl.e21030. ISSN 0732-183X. S2CID 236398737.

[11] Kim YJ, Li W, Zhelev DV, Mellors JW, Dimitrov DS, Baek DS (2023-02-27). "Chimeric antigen receptor-T cells are effective against CEACAM5 expressing non-small cell lung cancer cells resistant to antibody-drug conjugates". Frontiers in Oncology. 13: 1124039. doi:10.3389/fonc.2023.1124039. PMC 10010383. PMID 36923424.

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CEACAM5

Functions

See also

References

Further reading

External links