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Structures	Swiss-model
Domains	InterPro

CD72 molecule
CD72 molecule
Identifiers
Symbol	CD72
NCBI gene	971
HGNC	1696
OMIM	107272
RefSeq	NM_001782
UniProt	P21854
Other data
Locus	Chr. 9 p
Structures
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Structures	Swiss-model
Domains	InterPro

CD72 (Cluster of Differentiation 72), also known in murine biology as Lyb-2, is a protein active in the immune system of animals. It consists of two identical halves, each of about 39-43 kD, and is a C-type lectin. Its primarily locus of expression is B-cells (from the pro-B through the mature B-cell stage), where it appears to mediate aspects of B-cell - T-cell interaction. It is a ligand for CD5.^[1]

CD72 is a regulatory protein on B lymphocytes. The cytoplasmic tail of CD72 contains two potential immunoreceptor tyrosine-based inhibitory motifs, one of which has been shown to recruit the tyrosine phosphatase SHP- 1. These features suggest a negative regulatory role for CD72. CD72 is a nonredundant regulator of B-cell development and a negative regulator of B-cell responsiveness.^[2]

References

^ Abbas AK, Licktman A (2003). Cellular and Molecular Immunology (5th ed.). Saunders. p. 512. ISBN 978-0-7216-0008-6.
^ Parnes JR, Pan C (August 2000). "CD72, a negative regulator of B-cell responsiveness". Immunological Reviews. 176 (1): 75–85. doi:10.1034/j.1600-065x.2000.00608.x. PMID 11043769. S2CID 29775275.