1FG9, 1FYH, 1JRH
3459
15979
ENSG00000027697
ENSMUSG00000020009
P15260
P15261
NM_000416NM_001363526NM_001363527
NM_010511
NP_000407NP_001350455NP_001350456
NP_034641
Interferon gamma receptor 1 (IFNGR1) also known as CD119 (Cluster of Differentiation 119), is a protein that in humans is encoded by the IFNGR1 gene.[5][6][7]
The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages. IFNGR2, encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor.[5]
Interferon gamma receptor 1 has been shown to interact with Interferon-gamma.[8][9]
Mutations in the IFNGR1 gene can lead to extreme susceptibility to Mycobacterial infections.[10][11] All known mutations and common variations in the IFNGR1 are present in the IFNGR1 mutation database.[12][13]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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