Enzyme-linked receptor

An enzyme-linked receptor, also known as a catalytic receptor, is a transmembrane receptor, where the binding of an extracellular ligand causes enzymatic activity on the intracellular side.[1] Hence a catalytic receptor is an integral membrane protein possessing both catalytic, and receptor functions.[2]

They have two important domains, an extra-cellular ligand binding domain and an intracellular domain, which has a catalytic function; and a single transmembrane helix. The signaling molecule binds to the receptor on the outside of the cell and causes a conformational change on the catalytic function located on the receptor inside the cell.

Examples of the enzymatic activity include:

Types

The following is a list of the five major families of catalytic receptors:

Family Member Gene Catalytic activity Endogenous ligands Synthetic ligands
Erb[4] ErbB1 (epidermal growth factor receptor) EGFR tyrosine kinase EC 2.7.10.1 Epidermal growth factor, amphiregulin, betacellulin, epigen, epiregulin, HB-EGF, TGFa GW583340, gefitinib, erlotinib, tyrphostins AG879 and AG1478
ErbB2 ERBB2 "
ErbB3 ERBB3 " NRG-1, NRG-2 GW583340, gefitinib, erlotinib, tyrphostins AG879 and AG1478
ErbB4 ERBB4 " Betacellulin, epiregulin, HB-EGF, NRG-1, NRG-2, NRG-3, NRG-4 GW583340, gefitinib, erlotinib, tyrphostins AG879 and AG1478
GDNF (glial cell-derived neurotrophic factor)[5] GFRa1 GFRa1 " GDNF > neurturin > artemin
GFRa2 GFRa2 " Neurturin > GDNF
GFRa3 GFRa3 " Artemin
GFRa4 GFRa4 " Persephin
NPR (natriuretic peptide receptor)[6] NPR1 NPR1 guanylyl cyclase EC 4.6.1.2 Atrial natriuretic peptide
NPR2 NPR2 " C-type natriuretic peptide
NPR3 NPR3 " Atrial natriuretic peptide
NPR4 NPR4 " Uroguanylin
trk neurotrophin receptor[7] TrkA NTRK1 tyrosine kinase EC 2.7.10.1 Nerve growth factor > NT-3 GW441756, tyrphostin AG879
TrkB NTRK2 " Brain-derived neurotrophic factor, NT-4/NT-5 > NT-3
TrkC NTRK3 " NT-3
p75 NGFR " NGF, BDNF, NT3, NT4/5
Toll-like[8] TLR1 TLR1 "
TLR2 TLR2 " Peptidoglycan
TLR3 TLR3 " polyIC, polyinosine-polycytosine
TLR4 TLR4 " LPS, lipopolysaccharide derived from Gram-negative bacteria
TLR5 TLR5 " Flagellin
TLR6 TLR6 "
TLR7 TLR7 " resiquimod, imiquimod
TLR8 TLR8 "
TLR9 TLR9 " CpG, DNA enriched in cytosine:guanosine pairs
TLR10 TLR10 "

References

  1. ^ Dudek RW (1 November 2006). High-yield cell and molecular biology. Lippincott Williams & Wilkins. pp. 19–. ISBN 978-0-7817-6887-0. Retrieved 16 December 2010.
  2. ^ Alexander SP, Mathie A, Peters JA (February 2007). "Catalytic Receptors". Br. J. Pharmacol. 150 Suppl 1 (S1): S122–7. doi:10.1038/sj.bjp.0707205. PMC 2013840.
  3. ^ "lecture10". Archived from the original on 2007-05-25. Retrieved 2007-03-03.
  4. ^ Alexander SP, Mathie A, Peters JA (February 2007). "Catalytic receptors: ErbB family". Br. J. Pharmacol. 150 Suppl 1: S146. doi:10.1038/sj.bjp.0706476.
  5. ^ Alexander SP, Mathie A, Peters JA (February 2007). "Catalytic receptors: GDNF family". Br. J. Pharmacol. 150 Suppl 1: S147. doi:10.1038/sj.bjp.0706477.
  6. ^ Alexander SP, Mathie A, Peters JA (February 2007). "Catalytic receptors: Natriuretic peptide family". Br. J. Pharmacol. 150 Suppl 1: S148. doi:10.1038/sj.bjp.0706478.
  7. ^ Alexander SP, Mathie A, Peters JA (February 2007). "Catalytic receptors: Neurotrophin family". Br. J. Pharmacol. 150 Suppl 1: S149. doi:10.1038/sj.bjp.0706479.
  8. ^ Alexander SP, Mathie A, Peters JA (February 2007). "Catalytic receptors: Toll-like receptor family". Br. J. Pharmacol. 150 Suppl 1: S150. doi:10.1038/sj.bjp.0706480.

Read other articles:

Bhagwant Das

Amber Fort, di Amber, ibu kota dari Raja Bhagwant Das Maharaja Bhagawant Das (Rajasthani: राजा भगवंत दास) (27 Januari 1574 – 10 Desember 1589[1]) adalah pemimpin Kacchwaha dari Amber. Ia adalah salah satu keturunan dari Jai Singh II pendiri dari Jaipur. Kehidupan Ia adalah putra tertua dari Raja Ankitmal atau Bharmal dan menggantikannya setelah kematiannya. Raja Bhagwant adalah saudara tertua dari permaisuri Akbar Mariam-uz-Zamani atau yang dike...

 

نادي الميادين

نادي الميادين الاسم الكامل نادي الميادين دير الزور الرياضي تأسس عام 1975 الملعب ملعب الميادين(السعة: 30138) البلد سوريا  الدوري السوري الإدارة الرئيس جمال سعيد المدرب عمر الحمش تعديل مصدري - تعديل   نادي الميادين الرياضي هو نادي كرة قدم سوري من مدينة الميادين في محافظة دير...

 

Список орденов СССР

Ордена́ СССР — государственные награды Советского Союза, призванные поощрить за особые заслуги в коммунистическом строительстве, защите социалистического Отечества, а также за иные особые заслуги перед государством и обществом. Государственные награды СССР, кроме ...

Board of War

American colonial-era committee responsible for managing the Continental Army Not to be confused with Ministry of War (imperial China). Board of War and OrdnanceCommittee overviewFormedJanuary 24, 1776 (1776-01-24)DissolvedFebruary 7, 1781 (1781-02-07)[1]Superseding agencyUnited States Department of War The Board of War, also known as the Board of War and Ordnance, was created by the Second Continental Congress as a special standing committee to oversee t...

 

Area code 709

Telephone area code for Newfoundland and Labrador Signal Hill, Newfoundland Area code 709 is the telephone area code in the North American Numbering Plan (NANP) for the entire Canadian province of Newfoundland and Labrador. History The first telephone system was installed in Newfoundland in 1885, but domestic long-distance calls within the Dominion of Newfoundland could be placed on a limited basis only in 1921. The first long-distance call from Newfoundland to Canada was made on January 10, ...

 

Call Me by Your Name (film)

Call Me by Your NamePoster film Call Me by Your NameSutradaraLuca GuadagninoProduserEmilie GeorgesLuca GuadagninoJames IvoryMarco MorabitoHoward RosenmanPeter SpearsRodrigo TeixeiraDitulis olehWalter FasanoLuca GuadagninoJames IvoryBerdasarkanCall Me by Your Nameoleh André AcimanPemeranTimothée ChalametArmie HammerMichael StuhlbargAmira CasarEsther GarrelVictoire Du BoisPenata musikSufjan StevensSinematograferSayombhu MukdeepromPenyuntingWalter FasanoPerusahaanproduksiFrensy Film Comp...

Brian Kemp

Kemp pada 2017 Brian Porter Kemp (lahir 2 November 1963) adalah seorang pengusaha dan politikus Amerika Serikat yang menjabat sebagai gubernur negara bagian Georgia sejak Januari 2019.[1] Sebagai anggota Partai Republik, ia sebelumnya menjadi Sekretaris Negara Bagian Georgia dari 2010 sampai 2018 dan anggota Senat Negara Bagian Georgia dari 2003 sampai 2007. Referensi ^ Swearing-in dates of state legislators elected on November 6, 2018. Ballotpedia. Diarsipkan dari versi asli tanggal ...

 

Ronald Reagan Boyhood Home

Historic house in Illinois, United States United States historic placeRonald Reagan Boyhood HomeU.S. National Register of Historic Places Show map of IllinoisShow map of the United StatesLocation816 S. Hennepin Ave., Dixon, IllinoisCoordinates41°50′10″N 89°28′50.6″W / 41.83611°N 89.480722°W / 41.83611; -89.480722Arealess than one acreBuilt1891Architectural styleQueen AnneNRHP reference No.82002580[1]Added to NRHPMarch 26, 1982 The Ron...

 

Leviatano

Disambiguazione – Se stai cercando altri significati, vedi Leviatano (disambigua). La distruzione del Leviatano di Gustave Doré (1865) Il Leviatano (לִוְיָתָן‎, Līvəyāṯān, in ebraico tiberiense anche liwyāṯān, sempre col senso di contorto, malvagio, avvolto) è una creatura con la forma di un serpente marino, nota sia nella teologia che nella mitologia. È citato in diversi libri della Bibbia ebraica, inclusi i Salmi, il Libro di Giobbe, il Libro di Isaia e il Lib...

Французские Южные и Антарктические территории

Французские Южные и Антарктические территории фр. Terres australes et antarctiques françaises (Флаг ФЮАТ) (Герб ФЮАТ) Местоположение Администрация Административный центр Сен-Пьер или Порт-о-Франсэ (неофиц.) Префект Паскаль Болот(фр. Pascal Bolot) Округа 5 Статистика Площадь1 439 672без Земли Аде...

 

日本標準時間

日語寫法日語原文日本標準時假名にほんひょうじゅんじ平文式罗马字Nihon Hyōjunji此條目可参照日語維基百科相應條目来扩充。若您熟悉来源语言和主题，请协助参考外语维基百科扩充条目。请勿直接提交机械翻译，也不要翻译不可靠、低品质内容。依版权协议，译文需在编辑摘要注明来源，或于讨论页顶部标记{{Translated page}}标签。兵庫縣明石市的明石市立天文科學館（...

 

Indian Grove

Cet article est une ébauche concernant le bois et la forêt, l’archéologie, les Nord-Amérindiens et le Colorado. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. Pour l’article homonyme, voir Indian. Indian GrovePrésentationType Bosquet, site archéologiqueCivilisation Utes (?)Patrimonialité Inscrit au NRHP (2000)Smithsonian 5SH1035LocalisationLocalisation Comté de Saguache, Colorado  États-U...

Hoegaarden (pabrik bir)

Artikel ini sebatang kara, artinya tidak ada artikel lain yang memiliki pranala balik ke halaman ini.Bantulah menambah pranala ke artikel ini dari artikel yang berhubungan atau coba peralatan pencari pranala.Tag ini diberikan pada Desember 2022. HoegaardenBerkas:Hoegaarden.svgJenisPabrik birIndustriMinuman beralkoholDidirikan1445KantorpusatHoegaarden, BelgiaProdukBirPemilikAnheuser-Busch InBevSitus webhoegaarden.com Hoegaarden (/ˈhoʊɡɑːrdən/; Belanda: [ɦuˈɣaːrdə(n)]) adalah...

 

來自深淵 (漫畫)

此條目疑似由大量爱好者内容组成。 (2023年8月1日)維基百科不是不經篩選的資訊收集處。請幫助改進這個條目，使用中立的語氣（而不是愛好者或媒體報道的語氣），移除瑣碎的軼事與未經證實的評論、不合適的列表和链接收集等。如條目內有愛好者可能感興趣而不符維基百科收錄標準的內容，可考慮將該等內容移至其他專門描寫來自深淵 (漫畫)的百科或網站，或在不存在�...

 

1992 Los Angeles riots

Riots following the beating of Rodney King 1992 Los Angeles riotsAftermath of the riotsDateApril 29 – May 4, 1992 (6 days); 32 years agoLocationLos Angeles County, California, U.S.Caused by Four policemen acquitted of assaulting and beating Rodney King Killing of Latasha Harlins Racial tension in Los Angeles Methods Widespread rioting looting assault arson protests vandalism shootouts Resulted inRiots suppressed Many homes and businesses damaged, looted, or destroyed Resignation of chief Da...

ماركو فريتز

ماركو فريتز   معلومات شخصية الميلاد 3 أكتوبر 1977 (47 سنة)  مواطنة ألمانيا  الحياة العملية المهنة حكم كرة قدم  اللغات الألمانية  الرياضة كرة القدم  بلد الرياضة ألمانيا  تعديل مصدري - تعديل   ماركو فريتز (بالألمانية: Marco Fritz)‏ هو حكم كرة قدم ألماني، ولد في 3 أكتو...

 

Aeroporto Internazionale di Manila-Ninoy Aquino

Aeroporto Internazionale di Manila-Ninoy Aquinoaeroporto Codice IATAMNL Codice ICAORPLL DescrizioneTipoCivile GestoreManila International Airport Authority Stato Filippine Posizionenei pressi di Manila Altitudine23 m s.l.m. Coordinate14°30′31″N 121°01′10″E14°30′31″N, 121°01′10″E Mappa di localizzazioneRPLL Sito web mnlairport.ph. URL consultato il 29 maggio 2024. PisteOrientamento (QFU)LunghezzaSuperficie06/243.737calcestruzzo13/312.258calcestruzzo Statistic...

 

Manuel Velasco Coello

Mexican politician In this Spanish name, the first or paternal surname is Velasco and the second or maternal family name is Coello. This biography of a living person needs additional citations for verification. Please help by adding reliable sources. Contentious material about living persons that is unsourced or poorly sourced must be removed immediately from the article and its talk page, especially if potentially libelous.Find sources: Manuel Velasco Coello – news&#...

Centennial, Colorado

City in Colorado, United States Home rule municipality in Colorado, United StatesCentennial, ColoradoHome rule municipality[1]Centennial Civic Center located on East Arapahoe Road FlagMotto: Spirit of the PastCentennial in Arapahoe County, Colorado.CentennialLocation of Centennial in the United StatesShow map of ColoradoCentennialCentennial (the United States)Show map of the United StatesCoordinates: 39°35′26″N 104°52′09″W / 39.590568°N 104.869118°W&#x...

 

Jacques Duclaux

Pour les articles homonymes, voir Duclaux. Jacques DuclauxBiographieNaissance 14 mai 1877Lyon 6eDécès 13 juillet 1978 (à 101 ans)Paris 5eNom de naissance Jacques Eugène DuclauxNationalité FrançaisFormation Lycée Louis-le-GrandÉcole normale supérieureActivités Chimiste, professeur, biologiste, physicienPère Émile DuclauxMère Mary DuclauxAutres informationsA travaillé pour Collège de France (1931-1948)Institut PasteurÉcole pratique des hautes étudesInstitut de biologie ph...