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PTPRR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2A8B
Identifiers
Aliases	PTPRR, EC-PTP, PCPTP1, PTP-SL, PTPBR7, PTPRQ, protein tyrosine phosphatase, receptor type R, protein tyrosine phosphatase receptor type R
External IDs	OMIM: 602853; MGI: 109559; HomoloGene: 2135; GeneCards: PTPRR; OMA:PTPRR - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	70,920,738 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	116,110,837 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; right hemisphere of cerebellum; ; prefrontal cortex; ; entorhinal cortex; ; jejunal mucosa; ; mucosa of transverse colon; ; Brodmann area 46; ; testicle; ; orbitofrontal cortex; ; cerebellar vermis;
	Top expressed in
	Ileal epithelium; ; zygote; ; secondary oocyte; ; entorhinal cortex; ; perirhinal cortex; ; lobe of cerebellum; ; CA3 field; ; jejunum; ; transitional epithelium of urinary bladder; ; lumbar spinal ganglion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; phosphatase activity; protein binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity; protein kinase binding; hydrolase activity;
Cellular component	integral component of membrane; membrane; plasma membrane; cell junction; perinuclear region of cytoplasm; extracellular space; cytoplasm; cytosol;
Biological process	protein dephosphorylation; in utero embryonic development; ERBB2 signaling pathway; regulation of homophilic cell adhesion; negative regulation of ERK1 and ERK2 cascade; peptidyl-tyrosine dephosphorylation; negative regulation of epithelial cell migration; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	5801
	19279
	ENSG00000153233
	ENSMUSG00000020151
	Q15256
	Q62132
	NM_001207015; NM_001207016; NM_002849; NM_130846
NM_001161837; NM_001161838; NM_001161839; NM_001161840; NM_011217;
	NM_001358484
	NP_001193944; NP_001193945; NP_002840; NP_570897
NP_001155309; NP_001155310; NP_001155311; NP_001155312; NP_035347;
	NP_001345413
	Wikidata
View/Edit Human	View/Edit Mouse

Protein tyrosine phosphatase receptor-type R is an enzyme that in humans is encoded by the PTPRR gene.^[5]^[6]^[7]

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP. The similar gene predominantly expressed in mouse brain was found to associate with, and thus regulate the activity and cellular localization of MAP kinases. The rat counterpart of this gene was reported to be regulated by the nerve growth factor, which suggested the function of this gene in neuronal growth and differentiation.^[7]

Interactions

PTPRR has been shown to interact with MAPK7.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153233 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020151 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shiozuka K, Watanabe Y, Ikeda T, Hashimoto S, Kawashima H (Nov 1995). "Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase". Gene. 162 (2): 279–84. doi:10.1016/0378-1119(95)00306-Q. PMID 7557444.
^ van den Maagdenberg AM, Schepens JT, Schepens MT, Merkx GF, Darroudi F, Wieringa B, Geurts van Kessel A, Hendriks WJ (Jul 1999). "Assignment1 of the PTP-SL/PTPBR7 gene (Ptprr/PTPRR) to mouse chromosome region 8A2 by in situ hybridization". Cytogenet Cell Genet. 84 (3–4): 243–4. doi:10.1159/000015268. PMID 10393441. S2CID 35964382.
^ ^a ^b "Entrez Gene: PTPRR protein tyrosine phosphatase, receptor type, R".
^ Buschbeck M, Eickhoff J, Sommer MN, Ullrich A (Aug 2002). "Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway". J. Biol. Chem. 277 (33): 29503–9. doi:10.1074/jbc.M202149200. PMID 12042304.