DUSP12
Protein-coding gene in the species Homo sapiens
Dual specificity protein phosphatase 12 is an enzyme that in humans is encoded by the DUSP12 gene .[ 5] [ 6]
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine /threonine and phosphotyrosine residues. They negatively regulate members of the mitogen -activated protein (MAP ) kinase superfamily (MAPK/ERK , SAPK /JNK , p38), which is associated with cellular proliferation and differentiation .
Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization , and different modes of inducibility of their expression by extracellular stimuli.
This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase . It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.[ 6]
References
Further reading
Hasstedt SJ, Chu WS, Das SK, et al. (2008). "Type 2 diabetes susceptibility genes on chromosome 1q21-24" . Ann. Hum. Genet . 72 (Pt 2): 163–9. doi :10.1111/j.1469-1809.2007.00416.x PMID 18269685 . S2CID 272577 . Das SK, Chu WS, Hale TC, et al. (2006). "Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes" . Diabetes . 55 (9): 2631–9. doi :10.2337/db05-1369 PMID 16936214 . S2CID 24401721 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21. Bibcode :2006Natur.441..315G . doi :10.1038/nature04727 PMID 16710414 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Groom LA, Sneddon AA, Alessi DR, et al. (1996). "Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase" . EMBO J . 15 (14): 3621–32. doi :10.1002/j.1460-2075.1996.tb00731.x . PMC 451978 PMID 8670865 .
External links
Overview of all the structural information available in the PDB for UniProt : Q9UNI6 PDBe-KB .
