DUSP16
Protein-coding gene in humans
Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene .[ 5] [ 6] [ 7] [ 8]
The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.[supplied by OMIM][ 8]
Interactions
DUSP16 has been shown to interact with MAPK14 [ 9] [ 10] MAPK8IP1 .[ 11]
References
^ a b c ENSG00000111266 GRCh38: Ensembl release 89: ENSG00000280962, ENSG00000111266 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030203 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Tanoue T, Yamamoto T, Maeda R, Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs" . J Biol Chem . 276 (28): 26629–39. doi :10.1074/jbc.M101981200 PMID 11359773 . ^ Masuda K, Shima H, Watanabe M, Kikuchi K (Oct 2001). "MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein" . J Biol Chem . 276 (42): 39002–11. doi :10.1074/jbc.M104600200 PMID 11489891 . ^ Willoughby EA, Collins MK (Jul 2005). "Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2" . J Biol Chem . 280 (27): 25651–8. doi :10.1074/jbc.M501926200 PMID 15888437 . ^ a b "Entrez Gene: DUSP16 dual specificity phosphatase 16" .^ Tanoue T, Yamamoto T, Maeda R, Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs" . J. Biol. Chem . 276 (28). United States: 26629–39. doi :10.1074/jbc.M101981200 ISSN 0021-9258 . PMID 11359773 . ^ Masuda K, Shima H, Watanabe M, Kikuchi K (Oct 2001). "MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein" . J. Biol. Chem . 276 (42). United States: 39002–11. doi :10.1074/jbc.M104600200 ISSN 0021-9258 . PMID 11489891 . ^ Willoughby EA, Perkins Gordon R, Collins Mary K, Whitmarsh Alan J (Mar 2003). "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK" . J. Biol. Chem . 278 (12). United States: 10731–6. doi :10.1074/jbc.M207324200 ISSN 0021-9258 . PMID 12524447 .
Further reading
Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 7 (6): 347–55. doi :10.1093/dnares/7.6.347 PMID 11214970 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Willoughby EA, Perkins GR, Collins MK, Whitmarsh AJ (2003). "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK" . J. Biol. Chem . 278 (12): 10731–6. doi :10.1074/jbc.M207324200 PMID 12524447 . Masuda K, Shima H, Katagiri C, Kikuchi K (2003). "Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446" . J. Biol. Chem . 278 (34): 32448–56. doi :10.1074/jbc.M213254200 PMID 12794087 . Hoornaert I, Marynen P, Goris J, et al. (2003). "MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation". Oncogene . 22 (49): 7728–36. doi :10.1038/sj.onc.1207089 . PMID 14586399 . S2CID 20321362 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Katagiri C, Masuda K, Urano T, et al. (2005). "Phosphorylation of Ser-446 determines stability of MKP-7" . J. Biol. Chem . 280 (15): 14716–22. doi :10.1074/jbc.M500200200 PMID 15689616 .
External links
PDBe-KB provides an overview of all the structure information available in the PDB for Human Dual specificity protein phosphatase 16
