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PTPN13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D5G, 1Q7X, 1WCH, 2M0Z, 2M10, 3LNX, 3LNY, 3PDZ
Identifiers
Aliases	PTPN13, FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE, hPTP1E, protein tyrosine phosphatase, non-receptor type 13, protein tyrosine phosphatase non-receptor type 13
External IDs	OMIM: 600267; MGI: 103293; HomoloGene: 7909; GeneCards: PTPN13; OMA:PTPN13 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	86,815,171 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	103,746,169 bp
RNA expression pattern
	Top expressed in
	mucosa of paranasal sinus; ; urethra; ; human penis; ; palpebral conjunctiva; ; retinal pigment epithelium; ; skin of arm; ; renal medulla; ; trigeminal ganglion; ; gingival epithelium; ; mucosa of pharynx;
	Top expressed in
	corneal stroma; ; hair follicle; ; mucosa of urinary bladder; ; transitional epithelium of urinary bladder; ; retinal pigment epithelium; ; medullary collecting duct; ; skin of external ear; ; conjunctival fornix; ; skin of back; ; sciatic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphatase activity; phosphatidylinositol 3-kinase regulatory subunit binding; protein binding; phosphoprotein phosphatase activity; hydrolase activity;
Cellular component	cytoplasm; cell body; neuron projection; cell projection; extracellular exosome; cytoskeleton; nucleus; lamellipodium; plasma membrane; nucleoplasm;
Biological process	protein dephosphorylation; peptidyl-tyrosine dephosphorylation; regulation of phosphatidylinositol 3-kinase signaling; dephosphorylation; phosphatidylinositol biosynthetic process; negative regulation of protein phosphorylation; cellular response to cytokine stimulus; bicellular tight junction assembly;
	Sources:Amigo / QuickGO
Orthologs
	5783
	19249
	ENSG00000163629
	ENSMUSG00000034573
	Q12923
	Q64512
	NM_006264; NM_080683; NM_080684; NM_080685
	NM_011204
	NP_006255; NP_542414; NP_542415; NP_542416
	NP_035334
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 13 is an enzyme that in humans is encoded by the PTPN13 gene.^[5]^[6]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBalpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.^[6]

Interactions

PTPN13 has been shown to interact with PKN2.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163629 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034573 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Maekawa K, Imagawa N, Nagamatsu M, Harada S (Feb 1994). "Molecular cloning of a novel protein-tyrosine phosphatase containing a membrane-binding domain and GLGF repeats". FEBS Lett. 337 (2): 200–206. doi:10.1016/0014-5793(94)80273-4. PMID 8287977. S2CID 46269697.
^ ^a ^b "Entrez Gene: PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)".
^ Gross C, Heumann R, Erdmann K S (May 2001). "The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif". FEBS Lett. 496 (2–3): 101–104. doi:10.1016/S0014-5793(01)02401-2. ISSN 0014-5793. PMID 11356191. S2CID 205880882.