IFNAR1
Protein-coding gene in the species Homo sapiens
Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene .[ 5] [ 6]
Function
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for type I interferons , including interferon-alpha, -beta, and -lambda. Binding and activation of the receptor stimulates Janus protein kinases , which in turn phosphorylate several proteins, including STAT1 and STAT2 . The encoded protein also functions as an antiviral factor.[ 6]
Interactions
IFNAR1 has been shown to interact with:
References
^ a b c GRCh38: Ensembl release 89: ENSG00000142166 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022967 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Novick D, Cohen B, Rubinstein M (Jun 1994). "The human interferon alpha/beta receptor: characterization and molecular cloning". Cell . 77 (3): 391–400. doi :10.1016/0092-8674(94)90154-6 . PMID 8181059 . S2CID 140206806 . ^ a b "Entrez Gene: IFNAR1 interferon (alpha, beta and omega) receptor 1" .^ Abramovich C, Yakobson B, Chebath J, Revel M (Jan 1997). "A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor" . EMBO J . 16 (2): 260–6. doi :10.1093/emboj/16.2.260 . PMC 1169633 PMID 9029147 . ^ Li X, Leung S, Kerr IM, Stark GR (Apr 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling" . Mol. Cell. Biol . 17 (4): 2048–56. doi :10.1128/mcb.17.4.2048 . PMC 232052 PMID 9121453 . ^ Uddin S, Chamdin A, Platanias LC (Oct 1995). "Interaction of the transcriptional activator Stat-2 with the type I interferon receptor" . J. Biol. Chem . 270 (42): 24627–30. doi :10.1074/jbc.270.42.24627 PMID 7559568 . ^ Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ (Mar 1996). "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein" . EMBO J . 15 (5): 1064–74. doi :10.1002/j.1460-2075.1996.tb00444.x . PMC 450004 PMID 8605876 . ^ Richter MF, Duménil G, Uzé G, Fellous M, Pellegrini S (Sep 1998). "Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1" . J. Biol. Chem . 273 (38): 24723–9. doi :10.1074/jbc.273.38.24723 PMID 9733772 . ^ Kumar KG, Varghese B, Banerjee A, Baker DP, Constantinescu SN, Pellegrini S, Fuchs SY (Jul 2008). "Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif" . J. Biol. Chem . 283 (27): 18566–72. doi :10.1074/jbc.M800991200 PMC 2441555 PMID 18474601 .
Further reading
Bürglin TR, Barnes TM (1992). "Introns in sequence tags" . Nature . 357 (6377): 367–8. Bibcode :1992Natur.357..367B . doi :10.1038/357367a0 PMID 1350660 . S2CID 2693051 . Qiujing Yu; Yuliya V Katlinskaya; et al. (2015). "DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function" . Cell Reports . 11 (5): 785–797. doi :10.1016/j.celrep.2015.03.069 . PMC 4426031 PMID 25921537 . Lutfalla G, Gardiner K, Proudhon D, Vielh E, Uzé G (1992). "The structure of the human interferon alpha/beta receptor gene" . J. Biol. Chem . 267 (4): 2802–9. doi :10.1016/S0021-9258(18)45950-9 PMID 1370833 . Flores I, Mariano TM, Pestka S (1991). "Human interferon omega (omega) binds to the alpha/beta receptor" . J. Biol. Chem . 266 (30): 19875–7. doi :10.1016/S0021-9258(18)54862-6 PMID 1834641 . Lutfalla G, Roeckel N, Mogensen KE, Mattei MG, Uzé G (1990). "Assignment of the human interferon-alpha receptor gene to chromosome 21q22.1 by in situ hybridization". J. Interferon Res . 10 (5): 515–7. doi :10.1089/jir.1990.10.515 . PMID 2148760 . Uzé G, Lutfalla G, Gresser I (1990). "Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA". Cell . 60 (2): 225–34. doi :10.1016/0092-8674(90)90738-Z . PMID 2153461 . S2CID 54409221 . Colamonici O, Yan H, Domanski P, Handa R, Smalley D, Mullersman J, Witte M, Krishnan K, Krolewski J (1994). "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase" . Mol. Cell. Biol . 14 (12): 8133–42. doi :10.1128/mcb.14.12.8133 . PMC 359352 PMID 7526154 . Uddin S, Chamdin A, Platanias LC (1995). "Interaction of the transcriptional activator Stat-2 with the type I interferon receptor" . J. Biol. Chem . 270 (42): 24627–30. doi :10.1074/jbc.270.42.24627 PMID 7559568 . Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR (1995). "Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling" . J. Biol. Chem . 270 (37): 21606–11. doi :10.1074/jbc.270.37.21606 PMID 7665574 . Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ (1996). "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein" . EMBO J . 15 (5): 1064–74. doi :10.1002/j.1460-2075.1996.tb00444.x . PMC 450004 PMID 8605876 . Yang CH, Shi W, Basu L, Murti A, Constantinescu SN, Blatt L, Croze E, Mullersman JE, Pfeffer LM (1996). "Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor" . J. Biol. Chem . 271 (14): 8057–61. doi :10.1074/jbc.271.14.8057 PMID 8626489 . Abramovich C, Yakobson B, Chebath J, Revel M (1997). "A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor" . EMBO J . 16 (2): 260–6. doi :10.1093/emboj/16.2.260 . PMC 1169633 PMID 9029147 . Eantuzzi L, Eid P, Malorni W, Rainaldi G, Gauzzi MC, Pellegrini S, Belardelli F, Gessani S (1997). "Post-translational up-regulation of the cell surface-associated alpha component of the human type I interferon receptor during differentiation of peripheral blood monocytes: role in the biological response to type I interferon". Eur. J. Immunol . 27 (5): 1075–81. doi :10.1002/eji.1830270506 . PMID 9174595 . S2CID 6569287 . Gessani S, Borghi P, Fantuzzi L, Varano B, Conti L, Puddu P, Belardelli F (1997). "Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiation" . J. Leukoc. Biol . 62 (1): 49–53. doi :10.1002/jlb.62.1.49 PMID 9225992 . S2CID 31546644 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Krishnan K, Singh B, Krolewski JJ (1998). "Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor" . J. Biol. Chem . 273 (31): 19495–501. doi :10.1074/jbc.273.31.19495 PMID 9677371 . Richter MF, Duménil G, Uzé G, Fellous M, Pellegrini S (1998). "Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1" . J. Biol. Chem . 273 (38): 24723–9. doi :10.1074/jbc.273.38.24723 PMID 9733772 . Rani MR, Leaman DW, Han Y, Leung S, Croze E, Fish EN, Wolfman A, Ransohoff RM (1999). "Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase" . J. Biol. Chem . 274 (45): 32507–11. doi :10.1074/jbc.274.45.32507 PMID 10542297 .
