3WO4
8807
16174
ENSG00000115607
ENSMUSG00000026068
O95256
Q9Z2B1
NM_003853
NM_010553
NP_003844
NP_034683
Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene.[5][6]
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-κB and MAPK8 (JNK) in response to IL18.[5]
Variants at IL18RAP have been linked to susceptibility to Coeliac disease.[7]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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