4162
84004
ENSG00000076706
ENSMUSG00000032135
P43121
Q8R2Y2
NM_006500
NM_023061NM_001359530
NP_006491
NP_075548NP_001346459
CD146 (cluster of differentiation 146) also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. In humans, the CD146 protein is encoded by the MCAM gene.[5]
MCAM functions as a receptor for laminin alpha 4,[6] a matrix molecule that is broadly expressed within the vascular wall. Accordingly, MCAM is highly expressed by cells that are components of the blood vessel wall, including vascular endothelial cells, smooth muscle cells and pericytes. Its function is still poorly understood, but evidence points to it being part of the endothelial junction associated with the actin cytoskeleton. A member of the Immunoglobulin superfamily, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle.
Two isoforms exist (MCAM long (MCAM-1), and MCAM short, or MCAM-s) which differ in the length of their cytoplasmic domain. Activation of these isoforms seems to produce functional differences as well. Natural killer cells transfected with MCAM-1 demonstrate decreased rolling velocity and increased cell adhesion to an endothelial cell monolayer and increased microvilli formation while cells transfected with MCAM-s showed no change in adhesion characteristics. Since these characteristics are important in leukocyte extravasation, MCAM-1 may be an important part of the inflammatory response.
CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells.[7][8] CD146 T cells have been shown by Dagur and colleagues to produce IL-17.[9]
CD146 has been seen as a marker for mesenchymal stem cells isolated from multiple adult and fetal organs,[10] and its expression may be linked to multipotency; mesenchymal stem cells with greater differentiation potential express higher levels of CD146 on the cell surface.[11]
MCAM inhibits breast cancer progression.[12]
Normal melanocytes do not express MCAM and the expression of MCAM is first found in nevi and melanoma cells.[13] MCAM expression is positively correlated to melanoma progression at which the expression of MCAM is highest in metastatic melanoma cells. The significance of MCAM upregulation is evident in melanoma cells cultured in 3D skin reconstruct in which MCAM facilitates the migration of melanoma into the dermis. Without the expression of MCAM melanoma cells are controlled by keratinocytes in the epidermis that inhibit penetrance beyond the basement membrane. The control by keratinocytes are only achieved by E-cadherin expression on the surface of melanoma cells. Melanoma cells with functional E-cadherin on the surface can only exclusively grow in the epidermis as keratinocytes frequently downregulate the expression of MCAM on melanoma cells.[13]
Image sensor format Drawing showing the relative sizes of sensors used in most current digital cameras. Advanced Photo System type-C (APS-C) is an image sensor format approximately equivalent in size to the Advanced Photo System film negative in its C (Classic) format, of 25.1×16.7 mm, an aspect ratio of 3:2 and Ø 30.15 mm field diameter. It is therefore also equivalent in size to the Super 35 motion picture film format, which has the dimensions of 24.89 mm × 18.66 mm…
Questa voce o sezione sull'argomento tecnica cinematografica non cita le fonti necessarie o quelle presenti sono insufficienti. Puoi migliorare questa voce aggiungendo citazioni da fonti attendibili secondo le linee guida sull'uso delle fonti. Il doppiatore (al femminile doppiatrice)[1] è l'attore che presta la propria voce a personaggi, persone e ad altri attori nel doppiaggio di film, serie televisive, documentari, cartoni animati e videogiochi e, in generale, di qualunque conten…
Berikut adalah daftar anggota JKT48 yang meninggalkan grup pada tahun 2023. Pengunduran diri Alia Giselle Maharani dan Aulia Asyira Basarestu pada tanggal 3 April menjadikan mereka anggota-anggota pertama yang mundur sejak Vania Aurellia pada Desember 2020. Februari Foto Nama Panggilan Kelahiran Usia Generasi Perkenalan Tanggal Lulus Nama Fansclub Akun Twitter Akun Instagram Akun TikTok Dhea Angelia Dey Jakarta, Indonesia, (2001-08-18)18 Agustus 2001 22 tahun Ketujuh Si gadis Betawi asli, siapa …
Bridge in Pittsburgh, Pennsylvania, United States Roberto Clemente BridgeThe Bridge with Downtown Pittsburgh in the background.Coordinates40°26′44.1594″N 80°0′11.8794″W / 40.445599833°N 80.003299833°W / 40.445599833; -80.003299833CarriesSixth StreetCrossesAllegheny RiverLocaleAllegheny, Pennsylvania, United StatesOfficial nameRoberto Clemente BridgeOther name(s)Sixth Street BridgeNamed forRoberto ClementeMaintained byAllegheny CountyCharacteristicsDesignSuspen…
Part of the neuroendocrine system Short overview of thyroid homeostasis.[1] The hypothalamic–pituitary–thyroid axis (HPT axis for short, a.k.a. thyroid homeostasis or thyrotropic feedback control) is part of the neuroendocrine system responsible for the regulation of metabolism and also responds to stress. As its name suggests, it depends upon the hypothalamus, the pituitary gland, and the thyroid gland. The hypothalamus senses low circulating levels of thyroid hormone (Triiodothyron…
село Рахиня Країна Україна Область Івано-Франківська область Район Калуський район Громада Долинська громада Облікова картка картка Основні дані Засноване 1395 Населення 1144 Площа 14,56 км² Густота населення 78,57 осіб/км² Поштовий індекс 77514 Телефонний код +380 3477 Ге
Human settlement in EnglandWindmill HillBoundaries of the city council wardPopulation13,180 (2011.Ward)[1]OS grid referenceST593715Unitary authorityBristolCeremonial countyBristolRegionSouth WestCountryEnglandSovereign stateUnited KingdomPost townBRISTOLPostcode districtBS3Dialling code0117PoliceAvon and SomersetFireAvonAmbulanceSouth Western UK ParliamentBristol South List of places UK England Bristol 51°26′28″N 2°35′10″W / …
العلاقات العراقية الساموية العراق ساموا العراق ساموا تعديل مصدري - تعديل العلاقات العراقية الساموية هي العلاقات الثنائية التي تجمع بين العراق وساموا.[1][2][3][4][5] مقارنة بين البلدين هذه مقارنة عامة ومرجعية للدولتين: وجه المقارنة العراق سا…
United States historic placeMcCook YMCAU.S. National Register of Historic Places The building in 2010Show map of NebraskaShow map of the United StatesLocation424 Norris Avenue, McCook, NebraskaCoordinates40°12′06″N 100°37′33″W / 40.20167°N 100.62583°W / 40.20167; -100.62583 (McCook YMCA)Arealess than one acreBuilt1925 (1925)Built bySwanson & SudikArchitectWilliam N. BowmanArchitectural styleMission RevivalNRHP reference No.00000…
1988 film directed by Guilherme de Almeida Prado The Lady from the Shanghai CinemaCover of the VHS releaseDirected byGuilherme de Almeida PradoWritten byGuilherme de Almeida PradoProduced bySara SilveiraStarringMaitê ProençaAntônio FagundesCinematographyCláudio PortioliJosé Roberto EliezerEdited byJair Garcia DuarteMusic byHermelino NederProductioncompanyEmbrafilmeDistributed byEmbrafilmeRelease date September 1, 1988 (1988-09-01)[1][2] Running time115 minutes…
Die Liste der Slogans ’’’Liste der Slogans aus Präsidentschaftswahlkämpfen in den Vereinigten Staaten’’’ sammelt verschiedene Slogans und Wahlkampfmottos, die während der Präsidentschaftswahlen von den einzelnen Kandidaten genutzt wurden. Sie sind nach Jahren sortiert. Inhaltsverzeichnis 1 1840–1896 1.1 1840 1.2 1844 1.3 1848 1.4 1852 1.5 1856 1.6 1860 1.7 1864 1.8 1868 1.9 1872 1.10 1876 1.11 1884 1.12 1888 1.13 1892 1.14 1896 2 1900–1920 2.1 1900 2.2 1904 2.3 1908 2.4 1912 …
Documentary series about the Australia men's cricket team The TestGenreDocu-seriesDirected byAdrian BrownSheldon Wynne (co-director season 2)Starring Tim Paine Steve Smith David Warner Justin Langer Aaron Finch Country of originAustraliaOriginal languageEnglishNo. of seasons2No. of episodes12ProductionProducersMish ArmstrongAdrian BrownRichard OstroffProduction locationAustraliaRunning time43-61 minutesProduction companiesAmazon StudiosWhooshka MediaCricket AustraliaOriginal releaseNetworkAmazon…
← 2016 2024 → Eleição municipal de Vitória de Santo Antão em 2020 15 de novembro de 2020 Candidato Paulo Roberto Aglailson Júnior Partido MDB PSB Natural de Vitória de Santo Antão, PE Recife, PE Vice Professor Edmo Neves (PTB) Henrique Queiroz (Avante) Votos 40.665 26.532 Porcentagem 55,43% 36,16% Prefeito de Vitória de Santo Antão Titular Aglailson Júnior PSB Eleito Paulo Roberto MDB A eleição municipal do município de Vitória de Santo Antão em 2020 ocorreu no dia …
楊深秀(1849年4月24日—1898年9月28日),初名毓秀,同治十三年甲戌改名深秀,字漪邨(會試硃卷作衣純),又用里名自號儀村,號孴孴子,山西絳州聞喜縣人。生於道光二十九年四月初二日(1849年4月24日)戌時,行一,大行二,民籍,以廩生中式同治九年庚午科本省鄉試舉人第三名,以員外郎分刑部學習,會試中式第266名貢士,著有《晉中國都考》、《山西星度譜》、《聞…
Archaeological site in Virginia, United States United States historic placeNottoway Archeological Site (44SX6, 44SX7, 44SX98, 44SX162)U.S. National Register of Historic Places Property entranceNearest cityStony Creek, VirginiaArea25 acres (10 ha)NRHP reference No.88002181[1]Added to NRHPNovember 3, 1988 The Nottoway Archeological Site is an overlapping series of prehistoric Native American settlement sites near the town of Stony Creek in Sussex County, Virginia. The site, …
1993 studio album by Taj MahalWorld MusicStudio album by Taj MahalReleasedJune 1, 1993[1]GenreBlues, reggae, world musicLabelColumbiaTaj Mahal chronology Taj's Blues(1992) World Music(1993) Dancing the Blues(1993) Professional ratingsReview scoresSourceRatingAllMusic[1]The Penguin Guide to Blues Recordings[2] World Music is a compilation album by American blues artist Taj Mahal.[1] Track listing All tracks composed by Taj Mahal; except where indicated When…
Pemberontakan NienLokasiTiongkok UtaraHasil Kemenangan QingMelemahnya Dinasti QingPihak terlibat Dinasti Qing MongolTokoh dan pemimpin Zeng Guofan Li Hongzhang Zuo Zongtang ?Kekuatan ~50.000 Tentara ~ 40.000 TentaraKorban Lebih dari 1.000.000 tentara dan penduduk tewas Pemberontakan Nien (Hanzi: 捻軍起義; Pinyin: niǎn jūn qǐ yì; Wade–Giles: nien-chün ch'i-yi) adalah pemberontakan bersenjata yang meletus di Tiongkok utara dari tahun 1851 hingga 1868, dimulai pada tahun yang…
Airport in North Kalimantan, IndonesiaJuwata International AirportBandar Udara Internasional JuwataIATA: TRKICAO: WAQQWMO: 96509SummaryAirport typePublic / MilitaryOwnerGovernment of IndonesiaOperatorMinistry of TransportationServesTarakanLocationTarakan, North Kalimantan, IndonesiaTime zoneWITA (UTC+08:00)Elevation AMSL20 ft / 6 mCoordinates03°19′36″N 117°33′56″E / 3.32667°N 117.56556°E / 3.32667; 117.56556Websitetrk.informasibandara.orgMapsKal…
African TV channel Television channel CNBC AfricaCountrySouth AfricaBroadcast areaAfrican continentHeadquartersJohannesburg, South AfricaProgrammingPicture format4:3 576i SDTVOwnershipOwnerAfrica Business NewsHistoryLaunched1 June 2007 (2007-06-01)LinksWebsitecnbcafrica.comAvailabilityTerrestrialDStvChannel 410Streaming mediacnbcafrica.comwww.cnbcafrica.com Consumer News and Business Channel Africa (known as CNBC Africa) is an African pay television network launched on 1 June 2007…
Reverse bungee ride SlingShotView of an active SlingShot ride from the Gemini Midway at Cedar Point.Cedar PointAreaGemini MidwayStatusClosedSoft opening dateJune 2014Opening dateJuly 2, 2014 Kings IslandAreaOktoberfestStatusRemovedOpening date2002Closing date2022 CarowindsAreaCarousel ParkStatusOperatingOpening date2015 Canada's WonderlandAreaAction ZoneStatusOperatingOpening date2015 Ride statisticsManufacturerFuntimeModelSling ShotSpeed62 mph (100 km/h)Vehicles1Riders per vehicle2Hei…
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