CDH17

CDH17
Identifiers
Aliases	CDH17, CDH16, HPT-1, HPT1, cadherin 17
External IDs	OMIM: 603017; MGI: 1095414; HomoloGene: 56859; GeneCards: CDH17; OMA:CDH17 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	94,217,303 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	11,817,895 bp
RNA expression pattern
	Top expressed in
	mucosa of colon; ; mucosa of sigmoid colon; ; mucosa of ileum; ; jejunal mucosa; ; rectum; ; mucosa of transverse colon; ; duodenum; ; pancreatic ductal cell; ; secondary oocyte; ; appendix;
	Top expressed in
	ileum; ; intestinal villus; ; left colon; ; duodenum; ; epithelium of small intestine; ; crypt of lieberkuhn of small intestine; ; jejunum; ; migratory enteric neural crest cell; ; Paneth cell; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; transporter activity; metal ion binding; integrin binding; proton-dependent oligopeptide secondary active transmembrane transporter activity; cytoskeletal protein binding; protein homodimerization activity; cadherin binding;
Cellular component	integral component of membrane; membrane; cell surface; plasma membrane; basolateral plasma membrane; nucleus; cell junction; catenin complex;
Biological process	spleen development; marginal zone B cell differentiation; integrin-mediated signaling pathway; positive regulation of integrin activation by cell surface receptor linked signal transduction; germinal center B cell differentiation; B cell differentiation; adherens junction organization; oligopeptide transport; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; oligopeptide transmembrane transport; homophilic cell adhesion via plasma membrane adhesion molecules; cell adhesion; cell-cell junction assembly; cell-cell adhesion mediated by cadherin; cell-cell adhesion; cell morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	1015
	12557
	ENSG00000079112
	ENSMUSG00000028217
	Q12864
	Q9R100
	NM_001144663; NM_004063
	NM_019753
	NP_001138135; NP_004054
	NP_062727
	Wikidata
View/Edit Human	View/Edit Mouse

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.^[5]^[6]^[7]

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000079112 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028217 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
^ Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.
^ ^a ^b "Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)".