4RM8, 4RMA, 4RM9, 1NI2
7430
22350
ENSG00000092820
ENSMUSG00000052397
P15311
P26040
NM_001111077NM_003379
NM_009510
NP_001104547NP_003370
NP_033536
Ezrin also known as cytovillin or villin-2 is a protein that in humans is encoded by the EZR gene.[5]
The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contains an ERM domain.
The cytoplasmic peripheral protein encoded by this gene can be phosphorylated by protein-tyrosine kinase in microvilli and is a member of the ERM protein family. This protein serves as a linker between plasma membrane and actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization.[6]
The N-terminal domain (also called FERM domain) binds sodium-hydrogen exchanger regulatory factor (NHERF) protein (involving long-range allostery).[7] This binding can happen only when ezrin is in its active state. The activation of ezrin occurs in synergism of the two factors: 1) binding of the N-terminal domain to phosphatidylinositol(4,5)bis-phosphate (PIP2) and 2) phosphorylation of threonine T567 in the C-terminal domain.[8][9] Binding to actin filaments (via C-terminal) and to membrane proteins (via N-terminal) stabilizes the protein's conformation in its active mode. The membrane proteins like CD44 and ICAM-2 are indirect binding partners of ezrin, while EBP50 (ERM binding protein 50) can associate with ezrin directly.[10]
VIL2 has been shown to interact with:
This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.
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