Moesin
Protein-coding gene in the species Homo sapiens
Moesin is a protein that in humans is encoded by the MSN gene .[ 5] [ 6]
Moesin (for membrane-organizing extension spike protein) is a member of the ERM protein family which includes ezrin and radixin . ERM proteins appear to function as cross-linkers between plasma membranes and actin -based cytoskeletons .[ 7]
Moesin is localized to filopodia and other membranous protrusions that are important for cell–cell recognition and signaling and for cell movement.[ 7]
Moesin has FERM domain at N-terminal .
Interactions
Moesin has been shown to interact with:
References
^ a b c GRCh38: Ensembl release 89: ENSG00000147065 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031207 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lankes WT, Furthmayr H (Oct 1991). "Moesin: a member of the protein 4.1-talin-ezrin family of proteins" . Proc. Natl. Acad. Sci. U.S.A . 88 (19): 8297–301. Bibcode :1991PNAS...88.8297L . doi :10.1073/pnas.88.19.8297 PMC 52495 PMID 1924289 . ^ Amieva MR, Furthmayr H (Sep 1995). "Subcellular localization of moesin in dynamic filopodia, retraction fibers, and other structures involved in substrate exploration, attachment, and cell-cell contacts" . Exp. Cell Res . 219 (1): 180–96. doi :10.1006/excr.1995.1218 PMID 7628534 . ^ a b "Entrez Gene: MSN moesin" .^ Serrador JM, Nieto M, Alonso-Lebrero JL, del Pozo MA, Calvo J, Furthmayr H, Schwartz-Albiez R, Lozano F, González-Amaro R, Sánchez-Mateos P, Sánchez-Madrid F (Jun 1998). "CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts". Blood . 91 (12): 4632–44. doi :10.1182/blood.V91.12.4632 . PMID 9616160 . ^ Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S (Feb 1998). "Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2" . J. Cell Biol . 140 (4): 885–95. doi :10.1083/jcb.140.4.885 . PMC 2141743 PMID 9472040 . ^ Serrador JM, Alonso-Lebrero JL, del Pozo MA, Furthmayr H, Schwartz-Albiez R, Calvo J, Lozano F, Sánchez-Madrid F (Sep 1997). "Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization" . J. Cell Biol . 138 (6): 1409–23. doi :10.1083/jcb.138.6.1409 . PMC 2132557 PMID 9298994 . ^ Serrador JM, Vicente-Manzanares M, Calvo J, Barreiro O, Montoya MC, Schwartz-Albiez R, Furthmayr H, Lozano F, Sánchez-Madrid F (Mar 2002). "A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting" . J. Biol. Chem . 277 (12): 10400–9. doi :10.1074/jbc.M110694200 PMID 11784723 . ^ a b Wientjes FB, Reeves EP, Soskic V, Furthmayr H, Segal AW (Nov 2001). "The NADPH oxidase components p47(phox) and p40(phox) bind to moesin through their PX domain". Biochem. Biophys. Res. Commun . 289 (2): 382–8. doi :10.1006/bbrc.2001.5982 . PMID 11716484 . ^ Barreiro O, Yanez-Mo M, Serrador JM, Montoya MC, Vicente-Manzanares M, Tejedor R, Furthmayr H, Sanchez-Madrid F (Jun 2002). "Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes" . J. Cell Biol . 157 (7): 1233–45. doi :10.1083/jcb.200112126 . PMC 2173557 PMID 12082081 . ^ Gajate C, Mollinedo F (Mar 2005). "Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy" . J. Biol. Chem . 280 (12): 11641–7. doi :10.1074/jbc.M411781200 PMID 15659383 . ^ Gary R, Bretscher A (Aug 1995). "Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site" . Mol. Biol. Cell . 6 (8): 1061–75. doi :10.1091/mbc.6.8.1061 . PMC 301263 PMID 7579708 . ^ Gary R, Bretscher A (Nov 1993). "Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins" . Proc. Natl. Acad. Sci. U.S.A . 90 (22): 10846–50. Bibcode :1993PNAS...9010846G . doi :10.1073/pnas.90.22.10846 PMC 47875 PMID 8248180 .
Further reading
Tsukita S, Yonemura S (1997). "ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction". Curr. Opin. Cell Biol . 9 (1): 70–5. doi :10.1016/S0955-0674(97)80154-8 . PMID 9013673 . Vaheri A, Carpén O, Heiska L, Helander TS, Jääskeläinen J, Majander-Nordenswan P, Sainio M, Timonen T, Turunen O (1997). "The ezrin protein family: membrane-cytoskeleton interactions and disease associations". Curr. Opin. Cell Biol . 9 (5): 659–66. doi :10.1016/S0955-0674(97)80119-6 . PMID 9330869 . Matarrese P, Malorni W (2005). "Human immunodeficiency virus (HIV)-1 proteins and cytoskeleton: partners in viral life and host cell death" . Cell Death Differ . 12 (Suppl 1): 932–41. doi :10.1038/sj.cdd.4401582 PMID 15818415 . Gary R, Bretscher A (1995). "Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site" . Mol. Biol. Cell . 6 (8): 1061–75. doi :10.1091/mbc.6.8.1061 . PMC 301263 PMID 7579708 . Schwartz-Albiez R, Merling A, Spring H, Möller P, Koretz K (1995). "Differential expression of the microspike-associated protein moesin in human tissues". Eur. J. Cell Biol . 67 (3): 189–98. PMID 7588875 . Schneider-Schaulies J, Dunster LM, Schwartz-Albiez R, Krohne G, ter Meulen V (1995). "Physical association of moesin and CD46 as a receptor complex for measles virus" . J. Virol . 69 (4): 2248–56. doi :10.1128/JVI.69.4.2248-2256.1995 . PMC 188894 PMID 7884872 . Wilgenbus KK, Hsieh CL, Lankes WT, Milatovich A, Francke U, Furthmayr H (1994). "Structure and localization on the X chromosome of the gene coding for the human filopodial protein moesin (MSN)" . Genomics . 19 (2): 326–33. doi :10.1006/geno.1994.1065 PMID 8188263 . Gary R, Bretscher A (1993). "Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins" . Proc. Natl. Acad. Sci. U.S.A . 90 (22): 10846–50. Bibcode :1993PNAS...9010846G . doi :10.1073/pnas.90.22.10846 PMC 47875 PMID 8248180 . Dunster LM, Schneider-Schaulies J, Löffler S, Lankes W, Schwartz-Albiez R, Lottspeich F, ter Meulen V (1994). "Moesin: a cell membrane protein linked with susceptibility to measles virus infection" . Virology . 198 (1): 265–74. doi :10.1006/viro.1994.1029 . PMID 8259662 . Nakamura F, Amieva MR, Furthmayr H (1995). "Phosphorylation of threonine 558 in the carboxyl-terminal actin-binding domain of moesin by thrombin activation of human platelets" . J. Biol. Chem . 270 (52): 31377–85. doi :10.1074/jbc.270.52.31377 PMID 8537411 . Ott DE, Coren LV, Kane BP, Busch LK, Johnson DG, Sowder RC, Chertova EN, Arthur LO, Henderson LE (1996). "Cytoskeletal proteins inside human immunodeficiency virus type 1 virions" . J. Virol . 70 (11): 7734–43. doi :10.1128/JVI.70.11.7734-7743.1996 . PMC 190843 PMID 8892894 . Hecker C, Weise C, Schneider-Schaulies J, Holmes HC, ter Meulen V (1997). "Specific binding of HIV-1 envelope protein gp120 to the structural membrane proteins ezrin and moesin" . Virus Res . 49 (2): 215–23. doi :10.1016/S0168-1702(97)00039-7 . PMC 7126478 PMID 9213396 . Serrador JM, Alonso-Lebrero JL, del Pozo MA, Furthmayr H, Schwartz-Albiez R, Calvo J, Lozano F, Sánchez-Madrid F (1997). "Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization" . J. Cell Biol . 138 (6): 1409–23. doi :10.1083/jcb.138.6.1409 . PMC 2132557 PMID 9298994 . Reczek D, Berryman M, Bretscher A (1997). "Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family" . J. Cell Biol . 139 (1): 169–79. doi :10.1083/jcb.139.1.169 . PMC 2139813 PMID 9314537 . Murthy A, Gonzalez-Agosti C, Cordero E, Pinney D, Candia C, Solomon F, Gusella J, Ramesh V (1998). "NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins" . J. Biol. Chem . 273 (3): 1273–6. doi :10.1074/jbc.273.3.1273 PMID 9430655 . Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S (1998). "Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2" . J. Cell Biol . 140 (4): 885–95. doi :10.1083/jcb.140.4.885 . PMC 2141743 PMID 9472040 .
PDB gallery
1e5w : STRUCTURE OF ISOLATED FERM DOMAIN AND FIRST LONG HELIX OF MOESIN
1ef1 : CRYSTAL STRUCTURE OF THE MOESIN FERM DOMAIN/TAIL DOMAIN COMPLEX
1j19 : Crystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide
1sgh : Moesin FERM domain bound to EBP50 C-terminal peptide
2d10 : Crystal structure of the Radixin FERM domain complexed with the NHERF-1 C-terminal tail peptide
2d11 : Crystal structure of the Radixin FERM domain complexed with the NHERF-2 C-terminal tail peptide
2d2q : Crystal structure of the dimerized radixin FERM domain
2yvc : Crystal structure of the Radixin FERM domain complexed with the NEP cytoplasmic tail
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
