EIF4B

EIF4B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF4B, EIF-4B, PRO1843, eukaryotic translation initiation factor 4B
External IDsOMIM: 603928; MGI: 95304; HomoloGene: 83162; GeneCards: EIF4B; OMA:EIF4B - orthologs
Orthologs
SpeciesHumanMouse
Entrez

1975

75705

Ensembl

ENSG00000063046

ENSMUSG00000058655

UniProt

P23588

Q8BGD9

RefSeq (mRNA)

NM_001300821
NM_001417
NM_018507
NM_001330654

NM_145625

RefSeq (protein)

NP_001287750
NP_001317583
NP_001408

NP_663600

Location (UCSC)Chr 12: 53.01 – 53.04 MbChr 15: 101.98 – 102.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the EIF4B gene.[5]

Interactions

eIF4B has been shown to interact with and stimulate the activity of eIF4A and bind to the eIF3 complex through the eIF3A subunit.[6] This interaction results in the recruitment of the eukaryotic small ribosomal subunit (40S) to the mRNA which will in turn set the stage for the later steps leading to elongation.

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000063046 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058655 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: EIF4B eukaryotic translation initiation factor 4B".
  6. ^ Merrick WC (Oct 2015). "eIF4F: a retrospective". The Journal of Biological Chemistry. 290 (40): 24091–9. doi:10.1074/jbc.R115.675280. PMC 4591800. PMID 26324716.

Further reading


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