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RPS18
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 3J7R, 4D61, 4KZX, 4D5L, 4V5Z, 5FLX, 4UJD, 3J7P, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS18, D6S218E, HKE3, KE-3, KE3, S18, ribosomal protein S18
External IDs	OMIM: 180473; MGI: 98146; HomoloGene: 88764; GeneCards: RPS18; OMA:RPS18 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	33,276,511 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,174,975 bp
RNA expression pattern
	Top expressed in
	left ovary; ; right ovary; ; skin of leg; ; skin of abdomen; ; canal of the cervix; ; lymph node; ; ectocervix; ; uterine tube; ; lactiferous gland; ; vagina;
	Top expressed in
	ventricular zone; ; lip; ; blastocyst; ; yolk sac; ; morula; ; neural layer of retina; ; right kidney; ; tail of embryo; ; genital tubercle; ; granulocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	rRNA binding; protein binding; nucleic acid binding; RNA binding; structural constituent of ribosome; protein kinase binding;
Cellular component	cytoplasm; ribosome; membrane; focal adhesion; intracellular anatomical structure; small ribosomal subunit; extracellular exosome; nucleus; nucleoplasm; extracellular matrix; cytosol; cytosolic small ribosomal subunit; postsynaptic density; synapse;
Biological process	viral transcription; SRP-dependent cotranslational protein targeting to membrane; translational initiation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; protein biosynthesis; ribosome biogenesis; rRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	6222
	20084
ENSG00000226225; ENSG00000096150; ENSG00000231500; ENSG00000235650; ENSG00000223367;
	ENSG00000227794
	ENSMUSG00000008668
	P62269
	P62270
	NM_022551
	NM_011296; NM_138946
	NP_072045
	NP_035426
	Wikidata
View/Edit Human	View/Edit Mouse

40S ribosomal protein S18 is a protein that in humans is encoded by the RPS18 gene.^[5]^[6]^[7]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]