EIF2S2

EIF2S2
Identifiers
AliasesEIF2S2, EIF2, EIF2B, EIF2beta, PPP1R67, eIF-2-beta, eukaryotic translation initiation factor 2 subunit beta
External IDsOMIM: 603908; MGI: 1914454; HomoloGene: 2904; GeneCards: EIF2S2; OMA:EIF2S2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

8894

67204

Ensembl

ENSG00000125977

ENSMUSG00000074656

UniProt

P20042

Q99L45

RefSeq (mRNA)

NM_003908
NM_001316363
NM_001316364

NM_026030

RefSeq (protein)

NP_001303292
NP_001303293
NP_003899

NP_080306

Location (UCSC)Chr 20: 34.09 – 34.11 MbChr 2: 154.71 – 154.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.[5][6]

Function

Eukaryotic translation initiation factor 2 (eIF2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. eIF2 is composed of three subunits, alpha (α), beta (β, this article), and gamma (γ), with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the eIF2 complex for another round of initiation.[6]

Regulation

Both eIF2α and eIF2β expression is regulated by the NRF1 transcription factor.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125977 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074656 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pathak VK, Nielsen PJ, Trachsel H, Hershey JW (Sep 1988). "Structure of the beta subunit of translational initiation factor eIF-2". Cell. 54 (5): 633–9. doi:10.1016/S0092-8674(88)80007-2. PMID 3044606. S2CID 54414457.
  6. ^ a b "Entrez Gene: EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa".
  7. ^ Chiorini JA, Miyamoto S, Harkin SJ, Safer B (February 1999). "Genomic cloning and characterization of the human eukaryotic initiation factor-2beta promoter". J. Biol. Chem. 274 (7): 4195–201. doi:10.1074/jbc.274.7.4195. PMID 9933616.

Further reading


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