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MRPS22
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J9M
Identifiers
Aliases	MRPS22, C3orf5, COXPD5, GIBT, MRP-S22, RPMS22, GK002, mitochondrial ribosomal protein S22, ODG7
External IDs	OMIM: 605810; MGI: 1928137; HomoloGene: 57030; GeneCards: MRPS22; OMA:MRPS22 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	139,360,497 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	98,483,713 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right adrenal cortex; ; gonad; ; Achilles tendon; ; tibialis anterior muscle; ; left adrenal gland; ; endothelial cell; ; myocardium of left ventricle; ; deltoid muscle; ; left adrenal cortex;
	Top expressed in
	primary oocyte; ; medial ganglionic eminence; ; maxillary prominence; ; mandibular prominence; ; abdominal wall; ; renal corpuscle; ; facial motor nucleus; ; medullary collecting duct; ; ureter; ; atrioventricular valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of ribosome;
Cellular component	mitochondrial inner membrane; ribosome; mitochondrial ribosome; mitochondrion; mitochondrial small ribosomal subunit;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; biological process;
	Sources:Amigo / QuickGO
Orthologs
	56945
	64655
	ENSG00000175110
	ENSMUSG00000032459
	P82650
	Q9CXW2
	NM_020191; NM_001363857; NM_001363893
	NM_025485
	NP_064576; NP_001350786; NP_001350822
	NP_079761
	Wikidata
View/Edit Human	View/Edit Mouse

28S ribosomal protein S22, mitochondrial is a protein that in humans is encoded by the MRPS22 gene.^[5]^[6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175110 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032459 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Crisponi L, Deiana M, Loi A, Chiappe F, Uda M, Amati P, Bisceglia L, Zelante L, Nagaraja R, Porcu S, Ristaldi MS, Marzella R, Rocchi M, Nicolino M, Lienhardt-Roussie A, Nivelon A, Verloes A, Schlessinger D, Gasparini P, Bonneau D, Cao A, Pilia G (Feb 2001). "The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome". Nat Genet. 27 (2): 159–66. doi:10.1038/84781. PMID 11175783. S2CID 26750194.
^ ^a ^b "Entrez Gene: MRPS22 mitochondrial ribosomal protein S22".