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EEF1G
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PBU
Identifiers
Aliases	EEF1G, EF1G, GIG35, eukaryotic translation elongation factor 1 gamma
External IDs	OMIM: 130593; MGI: 1914410; HomoloGene: 20363; GeneCards: EEF1G; OMA:EEF1G - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	62,574,086 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	8,955,843 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; gonad; ; gastrocnemius muscle; ; skeletal muscle tissue; ; stromal cell of endometrium; ; skin of leg; ; skin of abdomen; ; muscle of thigh; ; left ovary;
	Top expressed in
	ventricular zone; ; yolk sac; ; blastocyst; ; lip; ; embryo; ; morula; ; esophagus; ; tail of embryo; ; dentate gyrus of hippocampal formation granule cell; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; cadherin binding; translation elongation factor activity; glutathione transferase activity;
Cellular component	cytoplasm; cytosol; extracellular exosome; membrane; endoplasmic reticulum; nucleus;
Biological process	translational elongation; response to virus; protein biosynthesis; glutathione metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1937
	67160
	ENSG00000254772
	ENSMUSG00000071644
	P26641
	Q9D8N0
	NM_001404
	NM_026007
	NP_001395
	NP_080283
	Wikidata
View/Edit Human	View/Edit Mouse

Elongation factor 1-gamma is a protein that in humans is encoded by the EEF1G gene.^[5]^[6]^[7]

Function

This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases.^[7]

Interactions

EEF1G has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000254772 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071644 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kumabe T, Sohma Y, Yamamoto T (July 1992). "Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19". Nucleic Acids Res. 20 (10): 2598. doi:10.1093/nar/20.10.2598. PMC 312399. PMID 1598220.
^ Sanders J, Maassen JA, Möller W (January 1993). "Elongation factor-1 messenger-RNA levels in cultured cells are high compared to tissue and are not drastically affected further by oncogenic transformation". Nucleic Acids Res. 20 (22): 5907–10. doi:10.1093/nar/20.22.5907. PMC 334453. PMID 1461723.
^ ^a ^b "Entrez Gene: EEF1G eukaryotic translation elongation factor 1 gamma".
^ ^a ^b ^c Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
^ ^a ^b Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ ^a ^b Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (February 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochem. Biophys. Res. Commun. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477.
^ Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM (August 2001). "FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10374–9. Bibcode:2001PNAS...9810374I. doi:10.1073/pnas.181222898. PMC 56968. PMID 11504921.