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RPS10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX
Identifiers
Aliases	RPS10, DBA9, S10, ribosomal protein S10
External IDs	OMIM: 603632; MGI: 1914347; HomoloGene: 788; GeneCards: RPS10; OMA:RPS10 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	34,426,069 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	27,855,643 bp
RNA expression pattern
	Top expressed in
	gonad; ; left ovary; ; right ovary; ; right uterine tube; ; canal of the cervix; ; lymph node; ; skin of abdomen; ; skin of leg; ; ectocervix; ; body of uterus;
	Top expressed in
	saccule; ; medial ganglionic eminence; ; Gonadal ridge; ; migratory enteric neural crest cell; ; otic placode; ; condyle; ; otic vesicle; ; fossa; ; mesenteric lymph nodes; ; vas deferens;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome; protein binding; RNA binding;
Cellular component	cytoplasm; ribosome; membrane; focal adhesion; cytosolic small ribosomal subunit; nucleolus; extracellular exosome; nucleus; nucleoplasm; extracellular matrix; cytosol;
Biological process	viral transcription; SRP-dependent cotranslational protein targeting to membrane; translational initiation; ribosomal small subunit assembly; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; protein biosynthesis; rRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	6204
	67097
	ENSG00000124614
	ENSMUSG00000052146
	P46783
	P63325
	NM_001204091; NM_001014; NM_001203245
	NM_025963; NM_001364934
	NP_001005; NP_001190174; NP_001191020
	NP_080239; NP_001351863
	Wikidata
View/Edit Human	View/Edit Mouse

40S ribosomal protein S10 is a protein that in humans is encoded by the RPS10 gene.^[5]^[6]^[7]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

Clinical significance

Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found.^[7] Mutations in the RPS10 gene can cause Diamond–Blackfan anemia, a congenital anemia sometimes associated with bone marrow failure.^[8]