EIF2A

EIF2A
Identifiers
AliasesEIF2A, EIF-2A, MST089, MSTP004, MSTP089, CDA02, eukaryotic translation initiation factor 2A
External IDsOMIM: 609234; MGI: 1098684; HomoloGene: 5969; GeneCards: EIF2A; OMA:EIF2A - orthologs
Orthologs
SpeciesHumanMouse
Entrez

83939

229317

Ensembl

ENSG00000144895

ENSMUSG00000027810

UniProt

Q9BY44

Q8BJW6

RefSeq (mRNA)

NM_032025
NM_001319043
NM_001319044
NM_001319045
NM_001319046

NM_001005509

RefSeq (protein)

NP_001305972
NP_001305973
NP_001305974
NP_001305975
NP_114414

NP_001005509

Location (UCSC)Chr 3: 150.55 – 150.59 MbChr 3: 58.43 – 58.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eukaryotic translation initiation factor 2A (eIF2A) is a protein that in humans is encoded by the EIF2A gene.[5][6][7] The eIF2A protein is not to be confused with eIF2α, a subunit of the heterotrimeric eIF2 complex. Instead, eIF2A functions by a separate mechanism in eukaryotic translation.

Function

eIF2A is a 65 kDa protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM][7] It may be important for translation initiation mediated by the HCV IRES under stress conditions, but this result has been debated.[8][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144895 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027810 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zoll WL, Horton LE, Komar AA, Hensold JO, Merrick WC (Oct 2002). "Characterization of mammalian eIF2A and identification of the yeast homolog". The Journal of Biological Chemistry. 277 (40): 37079–87. doi:10.1074/jbc.M207109200. PMID 12133843.
  6. ^ Merrick WC (Jun 1992). "Mechanism and regulation of eukaryotic protein synthesis". Microbiological Reviews. 56 (2): 291–315. doi:10.1128/MMBR.56.2.291-315.1992. PMC 372869. PMID 1620067.
  7. ^ a b "Entrez Gene: EIF2A eukaryotic translation initiation factor 2A".
  8. ^ Kim JH, Park SM, Park JH, Keum SJ, Jang SK (Jun 2011). "eIF2A mediates translation of hepatitis C viral mRNA under stress conditions". The EMBO Journal. 30 (12): 2454–64. doi:10.1038/emboj.2011.146. PMC 3116280. PMID 21556050.
  9. ^ Jaafar ZA, Oguro A, Nakamura Y, Kieft JS (December 2016). "Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling". eLife. 5: e21198. doi:10.7554/elife.21198. PMC 5238962. PMID 28009256.

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