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EIF2B1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ECS
Identifiers
Aliases	EIF2B1, EIF2B, EIF2BA, eukaryotic translation initiation factor 2B subunit alpha, EIF2Balpha
External IDs	OMIM: 606686; MGI: 2384802; HomoloGene: 1080; GeneCards: EIF2B1; OMA:EIF2B1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	123,633,766 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	124,717,194 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; monocyte; ; Achilles tendon; ; body of uterus; ; skin of hip; ; skin of thigh; ; right coronary artery; ; granulocyte; ; tibial arteries;
	Top expressed in
	zygote; ; secondary oocyte; ; morula; ; morula; ; primary oocyte; ; yolk sac; ; primitive streak; ; embryo; ; epiblast; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	translation initiation factor activity; guanyl-nucleotide exchange factor activity; protein binding; identical protein binding;
Cellular component	cytoplasm; cytosol; membrane; plasma membrane; eukaryotic translation initiation factor 2B complex;
Biological process	response to peptide hormone; response to heat; response to glucose; cell metabolism; oligodendrocyte development; protein biosynthesis; translational initiation; T cell receptor signaling pathway; regulation of translational initiation;
	Sources:Amigo / QuickGO
Orthologs
	1967
	209354
	ENSG00000111361
	ENSMUSG00000029388
	Q14232
	Q99LC8
	NM_001414
	NM_145371
	NP_001405
	NP_663346
	Wikidata
View/Edit Human	View/Edit Mouse

Translation initiation factor eIF-2B subunit alpha is a protein that in humans is encoded by the EIF2B1 gene.^[5]

Interactions

EIF2B1 has been shown to interact with EIF2B5.^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111361 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029388 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa".
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Anthony TG, Fabian JR, Kimball SR, Jefferson LS (June 2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta. 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID 10858531.