40S ribosomal protein S16
Protein-coding gene in the species Homo sapiens
RPS16 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0 , 4V6X , 5A2Q , 5AJ0 , 4KZY , 3J7R , 4D61 , 4KZX , 4D5L , 4V5Z , 5FLX , 4UJD , 3J7P , 4KZZ , 4UJE , 4UJC
Identifiers Aliases RPS16 External IDs OMIM : 603675 ; MGI : 98118 ; HomoloGene : 794 ; GeneCards : RPS16 ; OMA :RPS16 - orthologs Wikidata
Length: 146 amino acids40S ribosomal protein S16' is a protein that in humans is encoded by the RPS16 gene .[ 5] [ 6] [ 7]
Ribosomes , the organelles that catalyze protein synthesis , consist of a small 40S subunit and a large 60S subunit . Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S9P family of ribosomal proteins. It is located in the cytoplasm . As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[ 7]
Interactions
Ribosomal protein S16 is one of the proteins from the small ribosomal subunit. It belongs to a ribosomal protein family that is divided into three groups based on sequence similarity:
* Eubacterial S16.
* Algal and plant chloroplast S16.
* Cyanelle S16.
* Neurospora crassa mitochondrial S24 (cyt-21).
S16 proteins have about 100 amino-acid residues. There are two paralogues in Arabidopsis thaliana, RPS16-1 (chloroplastic) and RPS16-2 (targeted to the chloroplast and the mitochondrion)
[4].
RPS16 has been shown to interact with CDC5L .[ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000105193 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037563 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Batra SK, Metzgar RS, Hollingsworth MA (May 1991). "Molecular cloning and sequence analysis of the human ribosomal protein S16" . J Biol Chem . 266 (11): 6830– 3. doi :10.1016/S0021-9258(20)89575-1 PMID 2016298 . ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (August 1998). "A map of 75 human ribosomal protein genes" . Genome Res . 8 (5): 509– 23. doi :10.1101/gr.8.5.509 PMID 9582194 . ^ a b "Entrez Gene: RPS16 ribosomal protein S16" .^ Ajuh P, Kuster B, Panov K, Zomerdijk J C, Mann M, Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry" . EMBO J . 19 (23). ENGLAND: 6569– 81. doi :10.1093/emboj/19.23.6569 . ISSN 0261-4189 . PMC 305846 PMID 11101529 .
Further reading
Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol . 73 (11– 12): 933– 47. doi :10.1139/o95-101 . PMID 8722009 . Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene . 150 (2): 243– 50. doi :10.1016/0378-1119(94)90433-2 . PMID 7821789 . Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry" . Eur. J. Biochem . 239 (1): 144– 9. doi :10.1111/j.1432-1033.1996.0144u.x PMID 8706699 . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791– 806. doi :10.1101/gr.6.9.791 PMID 8889548 . Lei XH, Shen X, Xu XQ, Bernstein HS (2001). "Human Cdc5, a regulator of mitotic entry, can act as a site-specific DNA binding protein". J. Cell Sci . 113 Pt 24 (24): 4523– 31. doi :10.1242/jcs.113.24.4523 . PMID 11082045 . Ajuh P, Kuster B, Panov K, et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry" . EMBO J . 19 (23): 6569– 81. doi :10.1093/emboj/19.23.6569 . PMC 305846 PMID 11101529 . Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus" . Curr. Biol . 12 (1): 1– 11. Bibcode :2002CBio...12....1A . doi :10.1016/S0960-9822(01)00650-9 PMID 11790298 . S2CID 14132033 . Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes" . Genome Res . 12 (3): 379– 90. doi :10.1101/gr.214202 . PMC 155282 PMID 11875025 . Karan D, Kelly DL, Rizzino A, et al. (2002). "Expression profile of differentially-regulated genes during progression of androgen-independent growth in human prostate cancer cells" . Carcinogenesis . 23 (6): 967– 75. doi :10.1093/carcin/23.6.967 PMID 12082018 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol . 6 (2): 97– 105. doi :10.1038/ncb1086 . PMID 14743216 . S2CID 11683986 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature . 433 (7021): 77– 83. Bibcode :2005Natur.433...77A . doi :10.1038/nature03207 . PMID 15635413 . S2CID 4344740 . Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes" . Protein Sci . 14 (6): 1438– 46. doi :10.1110/ps.041293005 . PMC 2253395 PMID 15883184 . Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells" . Mol. Cell. Proteomics . 6 (4): 575– 88. doi :10.1074/mcp.M600249-MCP200 PMID 17220478 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 .
