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RPL35A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UG0, 4V6X, 5AJ0, 3J92, 4UJC, 3J7P, 4UJE, 3J7Q, 3J7R, 4D67, 4UJD, 4D5Y, 3J7O
Identifiers
Aliases	RPL35A, DBA5, L35A, ribosomal protein L35a, eL33
External IDs	OMIM: 180468; MGI: 1928894; HomoloGene: 129020; GeneCards: RPL35A; OMA:RPL35A - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	197,956,610 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	32,880,559 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; left ovary; ; skin of hip; ; right ovary; ; ganglionic eminence; ; canal of the cervix; ; endothelial cell; ; monocyte; ; right uterine tube; ; body of uterus;
	Top expressed in
	thymus; ; lens; ; spleen; ; yolk sac; ; ventricular zone; ; lip; ; bone marrow; ; ileum; ; uterus; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; tRNA binding; RNA binding; structural constituent of ribosome;
Cellular component	cytosol; ribosome; membrane; intracellular anatomical structure; cytosolic large ribosomal subunit; extracellular exosome; extracellular matrix;
Biological process	viral transcription; SRP-dependent cotranslational protein targeting to membrane; ribosomal large subunit biogenesis; translational initiation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; protein biosynthesis; rRNA processing; cytoplasmic translation;
	Sources:Amigo / QuickGO
Orthologs
	6165
	57808
	ENSG00000182899
	ENSMUSG00000060636
	P18077
	O55142
	NM_000996; NM_001316311
	NM_001130484; NM_001130485; NM_021338
	NP_000987; NP_001303240
	NP_001123956; NP_001123957; NP_067313
	Wikidata
View/Edit Human	View/Edit Mouse

60S ribosomal protein L35a is a protein that in humans is encoded by the RPL35A gene.^[5]^[6]^[7]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Transcript variants utilizing alternative transcription initiation sites and alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182899 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060636 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Feo S, Davies B, Fried M (Jun 1992). "The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome". Genomics. 13 (1): 201–7. doi:10.1016/0888-7543(92)90221-D. PMID 1577483.
^ Colombo P, Read M, Fried M (Sep 1996). "The human L35a ribosomal protein (RPL35A) gene is located at chromosome band 3q29-qter". Genomics. 32 (1): 148–50. doi:10.1006/geno.1996.0093. PMID 8786106.
^ ^a ^b "Entrez Gene: RPL35A ribosomal protein L35a".