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EEF1D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MVM, 2MVN, 2N51
Identifiers
Aliases	EEF1D, EF-1D, EF1D, FP1047, eukaryotic translation elongation factor 1 delta
External IDs	OMIM: 130592; MGI: 1913906; HomoloGene: 23404; GeneCards: EEF1D; OMA:EEF1D - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	143,599,541 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	75,781,405 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; apex of heart; ; left ovary; ; right ovary; ; body of pancreas; ; right lobe of thyroid gland; ; prostate; ; muscle layer of sigmoid colon; ; body of uterus; ; canal of the cervix;
	Top expressed in
	primitive streak; ; condyle; ; fossa; ; internal carotid artery; ; somite; ; endothelial cell of lymphatic vessel; ; aortic valve; ; ascending aorta; ; external carotid artery; ; hair follicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; heat shock protein binding; translation factor activity, RNA binding; signal transducer activity; translation elongation factor activity; protein binding; cadherin binding;
Cellular component	cytoplasm; endoplasmic reticulum; nucleus; eukaryotic translation elongation factor 1 complex; fibrillar center; cytosol;
Biological process	regulation of transcription, DNA-templated; regulation of cell death; translational elongation; mRNA transcription; transcription, DNA-templated; cellular response to ionizing radiation; positive regulation of I-kappaB kinase/NF-kappaB signaling; signal transduction; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
	1936
	66656
	ENSG00000104529; ENSG00000273594
	ENSMUSG00000055762
	P29692
	P57776
NM_001130053; NM_001130054; NM_001130055; NM_001130056; NM_001130057;
	NM_001195203; NM_001289950; NM_001960; NM_032378; NM_001317743; NM_001330646
NM_001285429; NM_001285430; NM_001285431; NM_001285432; NM_001285433;
	NM_001285434; NM_023240; NM_029663
NP_001123525; NP_001123527; NP_001123528; NP_001123529; NP_001182132;
	NP_001276879; NP_001304672; NP_001317575; NP_001951; NP_115754
NP_001272358; NP_001272359; NP_001272360; NP_001272361; NP_001272362;
	NP_001272363; NP_075729; NP_083939
	Wikidata
View/Edit Human	View/Edit Mouse

Elongation factor 1-delta is a protein that in humans is encoded by the EEF1D gene.^[5]

Function

This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit functions as guanine nucleotide exchange factor. It is reported that this subunit interacts with HIV-1 Tat, and thus it represses the translation of host-cell, but not HIV-1, mRNAs. Several alternatively spliced transcript variants have been found for this gene, however, the full length nature of only two variants has been determined.^[6]

Interactions

EEF1D has been shown to interact with Glycyl-tRNA synthetase,^[7] EEF1G^[8]^[9] and KTN1,^[10] and is predicted to interact with TMEM63A.^[11]

References

^ ^a ^b ^c ENSG00000273594 GRCh38: Ensembl release 89: ENSG00000104529, ENSG00000273594 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055762 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sanders J, Raggiaschi R, Morales J, Möller W (Jul 1993). "The human leucine zipper-containing guanine-nucleotide exchange protein elongation factor-1 delta". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1174 (1): 87–90. doi:10.1016/0167-4781(93)90097-W. PMID 8334168.
^ "Entrez Gene: EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)".
^ Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
^ Ong LL, Er CP, Ho A, Aung MT, Yu H (Aug 2003). "Kinectin anchors the translation elongation factor-1 delta to the endoplasmic reticulum". The Journal of Biological Chemistry. 278 (34): 32115–23. doi:10.1074/jbc.M210917200. PMID 12773547.
^ "String Database". Retrieved 16 May 2014.