MRPS30

MRPS30
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS30, MRP-S30, PAP, PDCD9, S30mt, mitochondrial ribosomal protein S30
External IDsOMIM: 611991; MGI: 1926237; HomoloGene: 9607; GeneCards: MRPS30; OMA:MRPS30 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

10884

59054

Ensembl

ENSG00000112996

ENSMUSG00000021731

UniProt

Q9NP92

Q9D0G0

RefSeq (mRNA)

NM_016640

NM_021556

RefSeq (protein)

NP_057724

NP_067531

Location (UCSC)Chr 5: 44.81 – 44.82 MbChr 13: 118.51 – 118.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

28S ribosomal protein S30, mitochondrial is a protein that in humans is encoded by the MRPS30 gene.[5][6][7]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112996 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021731 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Carim L, Sumoy L, Nadal M, Estivill X, Escarceller M (May 2000). "Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52". Cytogenet Cell Genet. 87 (1–2): 85–8. doi:10.1159/000015397. PMID 10640817. S2CID 28253818.
  6. ^ Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. CiteSeerX 10.1.1.501.8919. doi:10.1074/jbc.M100727200. PMID 11279123.
  7. ^ a b "Entrez Gene: MRPS30 mitochondrial ribosomal protein S30".

Further reading


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