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FZD9
Identifiers
Aliases	FZD9, CD349, FZD3, frizzled class receptor 9
External IDs	OMIM: 601766; MGI: 1313278; HomoloGene: 2619; GeneCards: FZD9; OMA:FZD9 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	73,436,120 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	135,280,084 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; muscle of thigh; ; gastrocnemius muscle; ; Amygdala; ; cingulate gyrus; ; anterior cingulate cortex; ; prefrontal cortex; ; C1 segment; ; Hypothalamus; ; right frontal lobe;
	Top expressed in
	rib; ; myotome; ; soleus muscle; ; lumbar subsegment of spinal cord; ; lumbar spine; ; ventricular zone; ; stria vascularis; ; plantaris muscle; ; larynx; ; extensor digitorum longus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; signal transducer activity; Wnt-protein binding; protein heterodimerization activity; transmembrane signaling receptor activity; G protein-coupled receptor activity; Wnt-activated receptor activity;
Cellular component	cytoplasm; membrane; plasma membrane; cell surface; perinuclear region of cytoplasm; filopodium membrane; endoplasmic reticulum membrane; Golgi apparatus; mitochondrial membranes; integral component of membrane; postsynapse; glutamatergic synapse;
Biological process	G protein-coupled receptor signaling pathway; Wnt signaling pathway; nervous system development; multicellular organism development; cell surface receptor signaling pathway; learning or memory; neuroblast proliferation; B cell differentiation; signal transduction; ossification; release of cytochrome c from mitochondria; positive regulation of bone mineralization; positive regulation of apoptotic process; negative regulation of neuron apoptotic process; regulation of cytosolic calcium ion concentration; negative regulation of mitochondrial depolarization; negative regulation of necroptotic process; positive regulation of canonical Wnt signaling pathway; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; regulation of skeletal muscle acetylcholine-gated channel clustering; negative regulation of skeletal muscle acetylcholine-gated channel clustering; bone regeneration; positive regulation of neural precursor cell proliferation; non-canonical Wnt signaling pathway; canonical Wnt signaling pathway; postsynapse organization; regulation of postsynaptic cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
	8326
	14371
	ENSG00000188763
	ENSMUSG00000049551
	O00144
	Q9R216
	NM_003508
	NM_010246
	NP_003499
	NP_034376
	Wikidata
View/Edit Human	View/Edit Mouse

Frizzled-9 (Fz-9) is a protein that in humans is encoded by the FZD9 gene.^[5]^[6]^[7] Fz-9 has also been designated as CD349 (cluster of differentiation 349).

Function

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188763 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049551 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang YK, Samos CH, Peoples R, Pérez-Jurado LA, Nusse R, Francke U (Mar 1997). "A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23". Human Molecular Genetics. 6 (3): 465–72. doi:10.1093/hmg/6.3.465. PMID 9147651.
^ Wang YK, Spörle R, Paperna T, Schughart K, Francke U (Apr 1999). "Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome". Genomics. 57 (2): 235–48. doi:10.1006/geno.1999.5773. PMID 10198163.
^ ^a ^b "Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)".

External links

"Frizzled Receptors: FZD₉". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2012-03-19. Retrieved 2008-12-04.
FZD9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)