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CD96
Identifiers
Aliases	CD96, TACTILE, CD96 molecule
External IDs	OMIM: 606037; MGI: 1934368; HomoloGene: 68489; GeneCards: CD96; OMA:CD96 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	111,665,750 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	45,940,614 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; blood; ; spleen; ; appendix; ; epithelium of colon; ; gallbladder; ; rectum; ; mucosa of transverse colon; ; bone marrow cells;
	Top expressed in
	thymus; ; seminiferous tubule; ; blood; ; mesenteric lymph nodes; ; ganglion of vagus nerve; ; pharynx; ; spleen; ; subcutaneous adipose tissue; ; secondary oocyte; ; jejunum;
	More reference expression data
	n/a
Orthologs
	10225
	84544
	ENSG00000153283
	ENSMUSG00000022657
	P40200; Q8WUE2
	Q3U0X8
	NM_005816; NM_198196; NM_001318889
	NM_032465
	NP_001305818; NP_005807; NP_937839; NP_001305818.1
	NP_115854
	Wikidata
View/Edit Human	View/Edit Mouse

CD96 (Cluster of Differentiation 96) or Tactile (T cell activation, increased late expression) is a protein that in humans is encoded by the CD96 gene.^[5] CD96 is a receptor protein which is expressed on T cells and NK cells and shares sequence similarity with CD226 (also known as DNAM-1).^[6] The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesion of activated T and NK cells to their target cells during the late phase of the immune response. It may also function in antigen presentation^{[citation needed]}. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. CD96 is a transmembrane glycoprotein that has three extracellular immunoglobulin-like domains and is expressed by all resting human and mouse NK cells. CD96 main ligand is CD155. CD 96 has approximately 20% homology with CD226 and competed for binding to CD155 with CD226.^[7]

Function

The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153283 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022657 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CD96 molecule". Retrieved 2018-07-03.
^ Fuchs A, Colonna M (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Seminars in Cancer Biology. 16 (5): 359–366. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340.
^ Martinet L, Smyth MJ (April 2015). "Balancing natural killer cell activation through paired receptors". Nature Reviews. Immunology. 15 (4): 243–254. doi:10.1038/nri3799. PMID 25743219. S2CID 20825600.